6 - Drug binding

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Last updated 8:44 PM on 4/29/26
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8 Terms

1
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State the history of the law of mass action.

1864 / Cato Guldberg & Peter Waage

2
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What is Bmax?

Maximal binding capacity of a tissue

3
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What is a femtomole?

1E-15 moles

4
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What is the measurement of drug affinity?

KD - equilibrium dissociation

5
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What is the equation for KD?

D + R <-> DR

6
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What is the relation between KD and affinity?

KD is inversely related to affinity / as KD does down, affinity does up.

7
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What does the Hill-Langmuir equation predict?

That plot of binding vs [D] will yield a rectangular hyperbola

8
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What is the alternative definition for KD?

Concentration of drug that occupies half of the receptor sites