FINALS: Intro to Malignancies (7)

del(5q)

Which cytogenetic abnormality is a key driver of MDS with isolated 5q syndrome?

• Chromosomes 5 and 7

• Chromosomes 8 and 18

• Chromosomes 20 and 13

Which chromosome abnormalities are commonly involved in MDS?

• Trisomy 8

• Monosomy 7

• Loss of Y chromosome

Which is a common single cytogenetic abnormality in MDS besides del(5q)?

IPSS and IPSS-R

Which prognostic scoring models are commonly used for MDS?

Less aggressively than high-risk patients

Patients with low-risk MDS are generally treated:

• Transfusions

• Erythropoiesis-stimulating agents

• Antibiotics and iron chelation

Which intervention may be used in MDS?

• Antithymocyte globulin

• Cyclosporine

Which immunosuppressive drugs may be used in selected MDS patients?

Less than 5%

In the FAB classification, refractory anemia (RA) typically has bone marrow blasts:

More than 15% ring sideroblasts

In FAB classification, refractory anemia with ring sideroblasts (RARS) is associated with:

5–20%

In FAB classification, refractory anemia with excess blasts (RAEB) has bone marrow blasts of:

20–30%

In FAB classification, RAEB in transformation (RAEB-T) has bone marrow blasts of:

MDS with isolated del(5q)

Which MDS subtype is associated with isolated del(5q)?

Unilineage dysplasia with less than 5% marrow blasts

In WHO classification, refractory anemia (RA) generally has:

Unilineage or multilineage dysplasia

Refractory cytopenia with multilineage dysplasia (RCMD) is characterized by:

10–19%

RAEB-2 is associated with bone marrow blasts of:

Myelodysplastic/myeloproliferative neoplasm

Chronic myelomonocytic leukemia (CMML) is classified as:

Less than 5%

In FAB classification, CMML-1 has peripheral blood blasts:

5–19%

In FAB classification, CMML-2 has peripheral blood blasts:

• Proliferation of granulocytic and monocytic lineages

• BCR-ABL1 mutation absence

• RAS/MAPK pathway mutations

Juvenile myelomonocytic leukemia is characterized by:

• Features of both MDS and MPN

• Leukocytosis with a majority of neutrophils

• Common multilineage dysplasia

Atypical chronic myeloid leukemia (BCR-ABL1 negative) is characterized by: