m2 - match disorders to types

T/F: histamine causes vasodilation

T

exposure to an allergen (type #)

type 1

blood transfusion reaction (type #)

type 2 - mismatched blood types

goodpasture syndrome

glomerulonephritis - type 2 (AB bind to extracellular connective tissue and activate complement system → mast cells produce cytokines → inflammation)

graves disease

type 2 - inappropriately stimulating the cell (thyroid gland inappropriately stimulated)

myasthenia gravis

type 2 - blocked/destroyed receptors

SLE - systemic lupus erythematosis

type 2 - antigens being a cellular size / aka attached to the cells

type 3 - antigens being a molecular size ab/ag immune complexes form and attach to any tissue, activating complement and damaging via inflammation

serum sickness

type 3 - first exposure to antibiotics, foods, drugs, venoms

arthurs reaction

type 3 - local response to repeated exposure to injected drug, vaccine, insect sting

post-strep glomerulonephritis

type 3

tuberculin skin test

T4 - delayed hypersensitivity

• antigen ingested by APC - presented to Th1 cells → activate th1 cells and release cytokines → summon macrophages → ROS → tissue destruction

contact dermatitis

t4 - delayed reaction

viral infection - hepatitis

t4 - cytotoxic T cells

• t cells travel through body and directly destroy body cells displaying antigen

bronchial asthma caused by environmental allergens like pollen

extrinsic - type 1

bronchial asthma caused by respiratory infections, cold air

NON-TYPE 1 - not caused by external allergen

what hypersensitivity type produces the butterfly rash in SLE?

type 3 - affects many body systems (joints, rashes)

hyperacute transplant rejection

immediate reaction - type 3

acute transplant rejection

type 4 - lymphocytes and macrophages found days/months after

chronic transplant rejection

type 4 - slow, progressive organ failure