306 week 3 meds - hematology

Ferrous sulfate

Oral iron supplement

absorbed in duodenum and jejunum, best on empty stomach, stored asferritin

PO

constipation, N, abd pain, dark stools, diarrhea

Iron sucrose

Parenteral iron replacement product

Incorporatied in to Hgb

IV

Hypotension, HA, nausea, dizziness

Ferric carboxymaltose

Parental iron replacement product

IV

Hypertension, nausea, flushing, and dizziness

Cyancocobalmin

Vitamin B12

Absorbed with instrisic factor, stored in liver

IM, SQ, PO

Injection-site reaction, hypokalemia (rare), HA

Folic Acid

Rapid GI absorption

PO, IV, IM

generally well tolerated, nausea, rash (rare)

Epoetin Alfa

Epogen, procrit

Erythropoesis stimulating agent

Stimulates bone marrow RBC production

IV, SQ

Hypertensions, thrombosis, stroke, MI, HA

Darbepoetin Alfa

Long acting erythropoeiss stimulating agent

IV, SQ
Hypertension, thromboembolic events, edema, HA

Erythropoetien EPO

Endogenous hematopoietic hormone

Produced primarily by kidneys

IV, SQ
Hyeprtension, thrombosis, icnreased CV risk

NSAIDS

ibusporfen

Nonsteroidal anti-inflammatory drugs

Hepatic metabolism, renal exretion, COX enzymes reducing prostaglandings

PO, IV

GI bleeding, ulceration, renal injury

For sickle cell

Fentanyl

Opioid analgesic

Rapid onset

IV, transdermal, buccal

Resp depression, sedation, constipation

for sickle cell

Morphine

Opioid analgesic

IV, PO, SQ
Resp depression, N/C, pruitus, hypotension

Sickle cell

Hydromorphone

Diladud

Opioid analgesic

More potent than morphine

IV, PO, SQ

Resp depression, sedation, C, N

Sickle cell

Hydroxyurea

Antimetabolite, well absorbed orally, increases fetal hemoglobin

PO

Myelosuppression, neutropenia, thrombocytopenia

sickle cell

L-glutamine

AA therapy, anti-sickling agenet

reduces oxidative stress in sickled RBC

PO
C/N/ abd pain, cough

Sickle cell

Crinzalizumab

monoclonal antibody, reduces vaso occlusion

IV

Arthryalgia, nausea, back pain, fever, infusion reacitons

Voxelotor

Antisickling agent, increases hemoglobin affinity for oxygen

PO

HA, diarrhea, rash, abd pain, fatigue

Sickle cell

Vitamin K antagonisht

Warfrin

Well absorbed, PO

bleeding bruising Gi upset

Contra - pregn, active bleeding, liver disease

Low molecular weight heparin

Enoxaparin

Predicatble anticoagulant effect

bleeding, anemia, injection site hematoma,

contra - active bleeding, historyof HIT

Direct factor Xa inhibitor

Apixaban

Rapid oral absoprtion, hepatic metabolism

PO

Bleeding, anemia, nausea

Contra- active bleeding, hepatic impairemen t

Antiplatelent COX1 inhibitor

Rapid GI absorption, irreversible platelet inhibition for 7-10 days

PO

Gi bleeding, gastric irritation, hemorrhage

contra.- active beleding, asprin allergy, peptic ulcer disease

Antiplatelet

Prodrug activated by CYP2C19 in liver

PO
Bleeding bruising diarrhea, rare TTP

Contra - active bleeding, severe liver disease

Leukopoetic growth factor

Filgrastim

Admin SQ or IV

Prevent and treat of chemotherpay induce neutropenia, severe chronic neutropenia, etc

Bone pain, leukocytosis, fever, injection site reactions

Granulocyte-=macrophage colony stimualting factor

Sargramostim

SQ or IV

Accelerate myeloid recovery agter bone marrow transplatn, chemo

stimulates neutrophils, monocytes, esionophils, macrophages

Fever, bone pain, edema, capillary leak syndreom, HTN, nausea

Thrombopoeitn receptor agonist

SQ once weekly

Stimulates plt production

For chronic immune thrombocytopenia

Headache, arthalgia, fatigue, dizziness