heme II: mature lymphoid neoplasms

what is the gold standard for mature lymphoid neoplasms

excisional biopsy

which lymphocyte proliferated in chronic lymphocytic leukemia (CLL)

B cell

what is the most common chronic leukemia

CLL

a combined score of greater than or equal to 4 is consistent with

CLL

these cells are consistent with

CLL

morphology of CLL

>85% lymphocytes, smudge cells

what can be used to fix smudge cells

albumin

what lymphocyte proliferates in adult T cell leukemia/lymphoma

T cell

prolymphocytic leukemia morphology

medium to large prolymphocytes with ample cytoplasm

what lymphocyte is hairy cell leukemia

B cell

the TRAP stain is specific for what leukemia

hairy cell leukemia

what disease correlates with these cells

hairy cell leukemia

a high level of TRAP in the blood plasma is a sign of

bone breakdown, most likely that cancer has spread to the bone

ATTL morphology

flower cell, accentuated convoluted nuclei, deeply basophilic cytoplasm

which leukemia has ‘flower’ cells

ATTL

which disease correlates with this cell

ATTL

burkitt lymphoma/leukemia is an aggressive cancer of mature ___

B cells

what leukemia is consistent with these cells

burkitt lymphoma/leukemia

follicular lymphoma (FL) is a disorder of germinal ___

B cells

morphology of FL cells

condensed chromatin with distinct nuclear clefts

mantle cell lymphoma mutation

t(11;14)

which lymphoma is consistent with these cells

follicular lymphoma

what is the most common form of NHL

diffuse large B cell lymphoma (DLBCL)

marginal zone lymphoma is a ___ lymphoma

B cell

which lymphoma is associated with chronic antigen stimulation by infection or autoimmunity

marginal zone lymphoma

H. pylori can be involved in which subtype of MZL

MALT

mycosis fungoides/sezary syndrome is the most common form of cutaneous ___ lymphomas

T cell

a disorder of CD4 T cells is consistent with

MF/SS

MF is confined to the ___

skin

which lymphoma has a ‘brain-like’ morphology in the peripheral blood

MF/SS

anaplastic large cell lymphoma is a ___ disorder

T cell

which lymphoma is associated with large pleomorphic cells

anaplastic large cell lymphoma (ALCL)

plasma cells produce

immunoglobulins

monoclonal gammopathy of undetermined significance is

benign

if MGUS progresses to IgG and IgA antibodies, it can turn into

multiple myeloma

if MGUS progresses to IgM antibodies, it can turn into

waldenstroms macroglobulinemia

a serum monoclonal protein <3g/dL is diagnostic of

MGUS

a serum monoclonal protein >3 g/dL is diagnostic of

MM

bone pain and fractures is characteristic of

multiple myeloma

disease progresses in multiple myeloma due to the production of

osteoclast activating factor (OAF) and other cytokines

there is an overproduction of immunoglobulin molecules in MM. this leads to

an imbalance of light chains of heavy chains

excess free light chains is also known as

bence jones protein

bence jones protein is found in

urine

morphology of MM in peripheral blood

rouleaux, circulating plasma cells

waldenstrom’s macroglobulinemia is characterized as aberrant secretion of

IgM

an increased secretion of IgM leads to

hyperviscosity

what mutation is present in WM

MYD88

>30% of plasma cells is present in

MM

which abbreviation summarizes multiple myeloma symptoms

CRAB

mucosal bleeding and blurred vision are symptoms of

WM

hodgkin’s lymphoma is caused by

epstein barr virus

hodgkins lymphoma morphology

reed sternberg cells

this cell is consistent with

hodgkin’s lymphoma

reed sternberg cells are of ___ origin

B cell

what markers are expressed by RS cells

CD15 and CD30