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Subcutaneous layer (Hypodermis)
Deep tissue layer that anchors skin to underlying structures, stores fat, insulates, and cushions against injury.
Keratinocytes
Epidermal cells that synthesize structural proteins and provide water resistance to the skin.
Melanocytes
Specialized cells in the stratum basale that synthesize protective pigment for the skin and hair.
Langerhans cells
Dendritic immune cells residing in the stratum spinosum that help defend against pathogens.
Merkel cells
Sensory receptor cells located in the stratum basale that detect light touch.
Stratum corneum
Outermost epidermal layer composed of flattened, dead, cornified cells that regularly shed.
Stratum lucidum
Thin, translucent layer of dead cells situated between the granulosum and corneum, present exclusively in thick skin.
Stratum granulosum
Middle epidermal layer containing keratohyalin and lamellar granules where cells begin to die.
Stratum spinosum
Epidermal layer characterized by bundles of pre-keratin filaments that give cells a prickly appearance; contains dendritic immune cells.
Stratum basale
Deepest epidermal layer attached to the dermis where rapid cell division produces new skin cells.
Basal cell carcinoma
Common, slow-growing skin cancer originating in the deepest stratum and typically presenting as a shiny bump.
Squamous cell carcinoma
Malignant skin cancer arising from keratinocytes that has the potential to spread.
Melanoma
Highly aggressive and dangerous skin cancer arising from pigment-producing cells.
Free edge
Distal portion of the nail plate extending beyond the tip of the finger or toe.
Nail plate
Hard, visible, translucent keratinized structure covering the dorsal surface of the digit.
Lunula
Pale, crescent-shaped area located at the proximal base of the nail plate.
Eponychium
Narrow band of epidermis (cuticle) extending onto the proximal border of the nail plate to protect against infection.
Nail matrix
Thickened proximal epithelial area beneath the nail root responsible for ongoing nail growth.
Dermal papillary layer
Superficial zone of the dermis forming ridges that project into the epidermis, housing capillary loops and tactile corpuscles.
Dermal reticular layer
Deeper, thicker dermal layer composed of dense irregular connective tissue, collagen bundles, and deep pressure receptors.
Meissner corpuscles
Encapsulated tactile nerve endings located in dermal papillae that respond to light touch.
Pacinian corpuscles
Lamellated sensory receptors found deep in the dermis that detect vibration and deep pressure.
Functions of hair
Sensory reception, physical protection from sunlight and foreign debris, and thermal insulation.
Thick skin
Hairless skin variety located exclusively on the palms of the hands and soles of the feet.
Arrector pili muscle
Small bundle of smooth muscle fibers attached to hair follicles whose contraction raises the hair shaft and produces goosebumps.
Sebaceous glands
Exocrine structures associated with hair follicles that secrete an oily lipid mixture to lubricate and waterproof the skin.
Eccrine sweat glands
Widely distributed tubular glands that open directly onto the skin surface to produce watery fluid for thermoregulation.
Apocrine sweat glands
Coiled tubular glands emptying into hair follicles in axillary and anogenital regions, active after puberty.
Ceruminous glands
Modified exocrine structures situated in the external acoustic meatus that produce earwax.
Keratin
Insoluble, fibrous structural protein that confers strength and water resistance to hair, nails, and the epidermis.
Melanin
Dark pigment produced in granules that determines skin, hair, and eye color while shielding DNA from UV radiation.
Sebum
Oily lipid secretion produced by cutaneous glands to soften skin and inhibit bacterial growth.
Cerumen
Waxy substance secreted into the ear canal that traps foreign particles and repels insects.