Conditions for Substitutions and Eliminations

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4 Terms

1
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Sn1 Optimal Conditions

3º or resonance stabilized

Weak Nucleophiles(waters and alcohols - nonbasic)

Polar protic solvents(water, methanol, ethanol)

Decent Leaving Groups(Halides)

Lower Heat

2
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Sn2 Optimal Conditions


1º or Methyl

Strong Concentrated Nucleophiles(OH-, I-, CN-)

Polar aprotic solvents(DMF, DMSO)

Good Leaving Groups(Halides)

Not excessive heat

3
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E1 Optimal Conditions

3º Substrates

Weak Nucleophiles(waters and alcohols - nonbasic)

Polar protic solvents(water, methanol, ethanol)

Favors production of E/trans alkenes

High High Temp to increase entropy

4
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E2 Optimal Conditions

1º or Methyl

Strong Concentrated Nucleophiles(OH-, I-, CN-)

β-hydrogen must be anti to leaving group

Favors production of more substituted alkenes

High High Temp to increase entropy