Protein Interactions & Misfolding Summary

Flashcards summarizing the key concepts of protein interactions and misfolding, including definitions and examples.

Protein-Protein Interactions

Critical for most cellular processes; can be transient or long-lasting.

3 Types of Protein Interactions

1. Direct surface interaction 2. Linear motifs 3. Modular domains

Hydrophobic burial

A force that contributes to protein interactions by burying hydrophobic residues.

Fibronectin

An example of a protein with normal beta-strand meshes that can be hijacked by pathogens.

Protein Misfolding

The process where misfolded beta-strands form stable aggregates, linked to diseases.

Prion Diseases (TSEs)

Infectious protein-based diseases caused by the PrP protein.

PrPSc

The infectious form of the prion protein that is beta-sheet-rich and forms aggregates.

GPI Anchor

A membrane-bound structure involved in adhesion, stress protection, and signaling.

Amyloids

Insoluble fibrous protein aggregates characterized by a cross-beta structure.

Alzheimer's Disease

A condition where Abeta forms plaques from AbetaPP cleavage.

Folding Energy Landscape

The concept that depicts a comparison between the entropic funnel of protein folding and the complex aggregation landscape.