Pharmacology of Muscarinic, Nicotinic, Adrenergic Agents and Insecticides

Methacholine

Treats: Bronchospasm test for asthma | MOA: Muscarinic agonist (ACh mimetic) | Selectivity: Nonselective muscarinic

Carbechol

Treats: Glaucoma, miosis during surgery | MOA: Muscarinic agonist (ACh mimetic) | Selectivity: Muscarinic & nicotinic receptor agonist

Bethanechol

Treats: Postsurgical urinary retention, abdominal distention | MOA: Muscarinic agonist (ACh mimetic) | Selectivity: Nonselective muscarinic

Pilocarpine

Treats: Glaucoma, dry mouth | MOA: Muscarinic agonist | Selectivity: M3 selective

Cevimeline

Treats: Dry mouth | MOA: Muscarinic agonist | Selectivity: M1 & M3 selective

Physostigmine

Treats: Glaucoma | MOA: Reversible AChE inhibitor

Neostigmine

Treats: Myasthenia gravis, post-op urinary retention and abdominal distention | MOA: Reversible AChE inhibitor | Note: Cannot cross BBB

Pyridostigmine

Treats: Myasthenia gravis | MOA: Reversible AChE inhibitor | Note: Cannot cross BBB

Carbaryl

Treats: Insecticide, flea/tick control | MOA: Reversible AChE inhibitor

Donepezil

Treats: Alzheimer's disease and dementia | MOA: Reversible AChE inhibitor

Rivastigmine

Treats: Alzheimer's disease and dementia | MOA: Reversible AChE inhibitor

Malathion

Treats: Insecticide | MOA: Irreversible AChE inhibitor

Diazinon

Treats: Insecticide | MOA: Irreversible AChE inhibitor

Schradan

Treats: Insecticide | MOA: Irreversible AChE inhibitor

Parathion

Treats: Insecticide | MOA: Irreversible AChE inhibitor

Pralidoxime

Treats: Poisoning with irreversible AChE inhibitor | MOA: AChE reactivator and catalytic scavenger

Atropine

Treats: Bradycardia, pre-surgical reduction of secretions, AChE poisoning | MOA: Muscarinic antagonist

Scopolamine

Treats: Motion sickness, GI spasms, pre-surgery secretion reduction | MOA: Muscarinic antagonist

Homatropine

Treats: Pupil dilation, AChE poisoning | MOA: Muscarinic antagonist

Glycopyrrolate

Treats: Peptic ulcer | MOA: Muscarinic antagonist

Tiotropium

Treats: COPD bronchospasm | MOA: Muscarinic antagonist

Umeclidinium

Treats: COPD maintenance | MOA: Muscarinic antagonist

Ipratropium

Treats: COPD maintenance | MOA: Muscarinic antagonist

Aclidinium

Treats: COPD maintenance | MOA: Muscarinic antagonist

Trospium

Treats: Overactive bladder | MOA: Muscarinic antagonist

Oxybutynin

Treats: Overactive bladder | MOA: Muscarinic antagonist

Darifenacin

Treats: Overactive bladder | MOA: Muscarinic antagonist

Fesoterodine

Treats: Overactive bladder | MOA: Muscarinic antagonist

Solifenacin

Treats: Overactive bladder | MOA: Muscarinic antagonist

Cobenfy

Treats: Schizophrenia | MOA: Muscarinic agonist (xanomeline crosses BBB) + muscarinic antagonist (trospium does not cross BBB)

Tubocurarine

Treats: Muscle paralysis | MOA: Nicotinic antagonist | Selectivity: Skeletal muscle nicotinic receptors

Succinylcholine

Treats: Surgical muscle paralysis | MOA: Nicotinic antagonist | Selectivity: Skeletal muscle nicotinic receptors

Cisatracurium

Treats: Surgical muscle paralysis | MOA: Nicotinic antagonist | Selectivity: Skeletal muscle nicotinic receptors

Nicotine

Treats: Smoking cessation | MOA: Nicotinic agonist

Varenicline

Treats: Smoking cessation, dry eye disease | MOA: Nicotinic partial agonist

Norepinephrine

Treats: Hypotensive crisis | MOA: Adrenergic agonist | Selectivity: Alpha & Beta nonselective

Epinephrine

Treats: Hypotension, anaphylaxis, asthma | MOA: Adrenergic agonist | Selectivity: Nonselective (prefers beta)

Phenylephrine

Treats: Hypotension, nasal congestion | MOA: Adrenergic agonist | Selectivity: Alpha-1 selective

Metaraminol

Treats: Hypotension | MOA: Adrenergic agonist | Selectivity: Alpha-1 selective

Methoxamine

Treats: Hypotension | MOA: Adrenergic agonist | Selectivity: Alpha-1 selective

Xylometazoline

Treats: Red eye, nasal congestion | MOA: Adrenergic agonist | Selectivity: Alpha-1 selective

Oxymetazoline

Treats: Red eye, nasal congestion | MOA: Adrenergic agonist | Selectivity: Alpha-1 selective

Tetrahydrozoline

Treats: Red eye, nasal congestion | MOA: Adrenergic agonist | Selectivity: Alpha-1 selective

Naphazoline

Treats: Red eye, nasal congestion | MOA: Adrenergic agonist | Selectivity: Alpha-1 selective

Brimonidine

Treats: Glaucoma | MOA: Adrenergic agonist | Selectivity: Alpha-2 selective

Albuterol

Treats: Bronchodilation | MOA: SABA | Selectivity: Beta-2 selective

Pirbuterol

Treats: Bronchodilation | MOA: SABA | Selectivity: Beta-2 selective

Salmeterol

Treats: Bronchodilation | MOA: LABA | Selectivity: Beta-2 selective

Indacaterol

Treats: COPD | MOA: LABA | Selectivity: Beta-2 selective

Formoterol

Treats: COPD/asthma | MOA: LABA | Selectivity: Beta-2 selective

Vilanterol

Treats: COPD | MOA: LABA | Selectivity: Beta-2 selective

Mirabegron

Treats: Overactive bladder | MOA: Adrenergic agonist | Selectivity: Beta-3 selective

Vibegron

Treats: Overactive bladder | MOA: Adrenergic agonist | Selectivity: Beta-3 selective

Phenoxybenzamine

Treats: Pheochromocytoma | MOA: Nonselective alpha antagonist

Prazosin

Treats: HTN, BPH | MOA: Alpha-1 selective antagonist

Terazosin

Treats: HTN, BPH | MOA: Alpha-1 selective antagonist

Doxazosin

Treats: HTN, BPH | MOA: Alpha-1 selective antagonist

Alfuzosin

Treats: BPH | MOA: Alpha-1A selective antagonist

Silodosin

Treats: BPH | MOA: Alpha-1A selective antagonist

Propranolol

Treats: HTN, angina, CHF, stage fright | MOA: Beta-blocker | Selectivity: Nonselective (Gen 1)

Bunolol

Treats: HTN, angina, CHF, stage fright | MOA: Beta-blocker | Selectivity: Nonselective (Gen 1)

Carteolol

Treats: HTN, angina, CHF, stage fright | MOA: Beta-blocker | Selectivity: Nonselective (Gen 1)

Metipranolol

Treats: HTN, angina, CHF, stage fright | MOA: Beta-blocker | Selectivity: Nonselective (Gen 1)

Nadolol

Treats: HTN, angina, CHF, stage fright | MOA: Beta-blocker | Selectivity: Nonselective (Gen 1)

Pindolol

Treats: HTN, angina, CHF, stage fright | MOA: Beta-blocker | Selectivity: Nonselective (Gen 1)

Penbutolol

Treats: HTN, angina, CHF, stage fright | MOA: Beta-blocker | Selectivity: Nonselective (Gen 1)

Acebutolol

Treats: HTN, angina, CHF | MOA: Beta-blocker | Selectivity: Beta-1 selective (Gen 2)

Atenolol

Treats: HTN, angina, CHF | MOA: Beta-blocker | Selectivity: Beta-1 selective (Gen 2)

Betaxolol

Treats: HTN, angina, CHF | MOA: Beta-blocker | Selectivity: Beta-1 selective (Gen 2)

Esmolol

Treats: HTN, angina, CHF | MOA: Beta-blocker | Selectivity: Beta-1 selective (Gen 2)

Metoprolol

Treats: HTN, angina, CHF | MOA: Beta-blocker | Selectivity: Beta-1 selective (Gen 2)

Bisoprolol

Treats: HTN, angina, CHF | MOA: Beta-blocker | Selectivity: Beta-1 selective (Gen 2)

Nebivolol

Treats: HTN | MOA: Beta-blocker | Selectivity: Cardioselective (Gen 3)

Carvedilol

Treats: HTN, CHF | MOA: Beta-blocker | Selectivity: Nonselective beta + alpha-1 (Gen 3)

Gepirone

Treats: MDD | MOA: Serotonin partial agonist | Selectivity: 5-HT1A

Ergotamine

Treats: Migraine | MOA: Serotonin receptor agonist | Selectivity: 5-HT1B/1D

Sumatriptan

Treats: Migraine | MOA: Serotonin receptor agonist | Selectivity: 5-HT1D

Eletriptan

Treats: Migraine | MOA: Serotonin receptor agonist | Selectivity: 5-HT1D

Zolmitriptan

Treats: Migraine | MOA: Serotonin receptor agonist | Selectivity: 5-HT1D

Rizatriptan

Treats: Migraine | MOA: Serotonin receptor agonist | Selectivity: 5-HT1D

Naratriptan

Treats: Migraine | MOA: Serotonin receptor agonist | Selectivity: 5-HT1D

Frovatriptan

Treats: Migraine | MOA: Serotonin receptor agonist | Selectivity: 5-HT1D

Risperidone

Treats: Schizophrenia, bipolar | MOA: Gen 2 antipsychotic | Selectivity: 5-HT2A & D2 antagonist

Clozapine

Treats: Schizophrenia, bipolar | MOA: Gen 2 antipsychotic | Selectivity: 5-HT2A & D2 antagonist

Olanzapine

Treats: Schizophrenia, bipolar | MOA: Gen 2 antipsychotic | Selectivity: 5-HT2A & D2 antagonist

Ondansetron

Treats: Nausea | MOA: 5-HT3 antagonist

Granisetron

Treats: Nausea | MOA: 5-HT3 antagonist

Palonosetron

Treats: Nausea | MOA: 5-HT3 antagonist

Dolasetron

Treats: Post-surgical nausea/vomiting | MOA: 5-HT3 antagonist

Alosetron

Treats: IBS (severe diarrhea in women) | MOA: 5-HT3 antagonist

Romasetron

Treats: IBS (severe diarrhea in men) | MOA: 5-HT3 antagonist

Phenelzine

Treats: MDD | MOA: MAOI | Selectivity: Nonselective (MAO-A & B)

Isocarboxazid

Treats: MDD | MOA: MAOI | Selectivity: Nonselective (MAO-A & B)

Tranylcypromine

Treats: MDD | MOA: MAOI | Selectivity: Nonselective (MAO-A & B)

Paragyline

Treats: Discontinued | MOA: MAOI | Selectivity: Nonselective (MAO-A & B)

Clorgyline

Treats: Research tool | MOA: MAOI | Selectivity: MAO-A selective

Deprenyl

Treats: MDD | MOA: MAOI | Selectivity: MAO-B selective

Selegiline

Treats: MDD | MOA: MAOI | Selectivity: MAO-B selective

Moclobemide

Treats: MDD | MOA: MAOI | Selectivity: MAO-A selective

Desipramine

Treats: MDD | MOA: TCA (SNRI) | Selectivity: NET >>> SERT