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anaphase
Stage of mitosis during which sister chromatids are separated from each other.
binary fission
Prokaryotic cell division process.
cell cycle
Ordered series of events involving cell growth and division that produces two new daughter cells.
cell plate
Structure formed during plant cell cytokinesis that leads to the formation of cell walls separating two daughter cells.
cell-cycle checkpoint
Mechanism that monitors the preparedness of a eukaryotic cell to advance through various cell-cycle stages.
centriole
Rod-like structure constructed of microtubules at the center of each animal cell centrosome.
centromere
Region at which sister chromatids are bound together in condensed chromosomes.
chromatid
Single DNA molecule of two strands of duplicated DNA held together at the centromere.
cleavage furrow
Constriction formed by an actin ring during cytokinesis in animal cells.
condensin
Proteins that help sister chromatids coil during prophase.
cyclin
Group of proteins that act with cyclin-dependent kinases to help regulate the cell cycle.
cyclin-dependent kinase (Cdk)
Group of protein kinases that help to regulate the cell cycle when bound to cyclin.
cytokinesis
Division of the cytoplasm following mitosis that forms two daughter cells.
diploid
Cell, nucleus, or organism containing two sets of chromosomes (2n).
FtsZ
Tubulin-like protein component of the prokaryotic cytoskeleton that is important in cytokinesis.
G0 phase
Distinct from the G1 phase; a cell in G0 is not preparing to divide.
G1 phase
First phase of interphase centered on cell growth during mitosis.
G2 phase
Third phase of interphase during which the cell undergoes final preparations for mitosis.
gamete
Haploid reproductive cell or sex cell (sperm, pollen grain, or egg).
gene
Physical and functional unit of heredity, a sequence of DNA that codes for a protein.
genome
Total genetic information of a cell or organism.
haploid
Cell, nucleus, or organism containing one set of chromosomes (n).
histone
Basic proteins found in the chromatin of all eukaryotic cells; associates with DNA to form nucleosomes.
homologous chromosomes
Chromosomes of the same morphology with genes in the same location.
interphase
Period of the cell cycle leading up to mitosis, including G1, S, and G2 phases.
karyokinesis
Mitotic nuclear division.
kinetochore
Protein structure associated with the centromere that attracts and binds spindle microtubules.
locus
Position of a gene on a chromosome.
metaphase
Stage of mitosis when chromosomes are aligned at the metaphase plate.
metaphase plate
Equatorial plane where chromosomes align during metaphase.
mitosis
Period of the cell cycle where duplicated chromosomes are separated into identical nuclei.
mitotic phase
Period during which duplicated chromosomes are distributed into two nuclei and cytoplasmic contents are divided.
mitotic spindle
Apparatus composed of microtubules that orchestrates the movement of chromosomes during mitosis.
nucleosome
Subunit of chromatin composed of DNA wrapped around histone proteins.
oncogene
Mutated version of a normal gene involved in the positive regulation of the cell cycle.
origin
Region of the prokaryotic chromosome where replication begins.
p21
Cell-cycle regulatory protein that inhibits the cell cycle.
p53
Regulatory protein that monitors DNA damage and may induce apoptosis.
prometaphase
Stage of mitosis when the nuclear membrane breaks down and spindle fibers attach to kinetochores.
prophase
Stage of mitosis when chromosomes condense and the mitotic spindle begins to form.
proto-oncogene
Normal gene that when mutated becomes an oncogene.
quiescent
Refers to a cell performing normal functions and not preparing for division.
retinoblastoma protein (Rb)
Regulatory molecule affecting the cell cycle by interacting with a transcription factor.
S phase
Stage of interphase during which DNA replication occurs.
septum
Structure formed in a bacterial cell as a precursor to the separation of the cell.
telophase
Stage of mitosis when chromosomes arrive at opposite poles and decondense.
tumor suppressor gene
Segment of DNA that codes for proteins that prevent uncontrolled division.
alternation of generations
Life-cycle type where the diploid and haploid stages alternate.
chiasmata
Structure that forms at the crossover points after genetic exchange.
cohesin
Proteins that seal sister chromatids together at centromeres until anaphase II.
crossover
Exchange of genetic material between nonsister chromatids.
fertilization
Union of two haploid cells from two organisms.
gametophyte
Multicellular haploid life-cycle stage that produces gametes.
germ cells
Specialized cells that produce gametes, like eggs or sperm.
interkinesis
Brief rest between meiosis I and meiosis II.
life cycle
Sequence of events in the development of an organism producing offspring.
meiosis
Nuclear division process resulting in four haploid cells.
meiosis I
First round of meiotic cell division where ploidy level is reduced.
meiosis II
Second round of meiotic division separating sister chromatids, producing four unique haploid cells.
recombination nodules
Protein assemblies that mark crossover events and mediate genetic recombination.
reduction division
Nuclear division producing daughter nuclei with half as many chromosome sets.
somatic cell
Cells of a multicellular organism except the gametes.
spore
Haploid cell that can produce a haploid multicellular organism or fuse with another spore.
sporophyte
Multicellular diploid life-cycle stage that produces haploid spores.
synapsis
Close association of homologous chromosomes during prophase I.
synaptonemal complex
Protein lattice between homologous chromosomes during prophase I.
tetrad
Two duplicated homologous chromosomes bound together by chiasmata.
allele
Gene variations arising by mutation at the same location on homologous chromosomes.
autosomes
Non-sex chromosomes.
blending theory of inheritance
Hypothetical inheritance pattern where parental traits blend in offspring.
codominance
Complete and simultaneous expression of both alleles in a heterozygote.
continuous variation
Inheritance pattern showing a range of trait values with small gradations.
dihybrid
Cross between two true-breeding parents differing in two characteristics.
discontinuous variation
Inheritance pattern where traits are distinct and transmitted independently.
dominant
Trait appearing the same whether homozygous or heterozygous.
dominant lethal
Inheritance where an allele is lethal in both homozygotes and heterozygotes.
epistasis
Interaction between genes wherein one gene masks the expression of another.
F1
First filial generation in a cross between parents.
F2
Second filial generation produced when F1 individuals are self-crossed.
genotype
Underlying genetic makeup of an organism.
hemizygous
Presence of only one allele for a characteristic.
heterozygous
Having two different alleles for a gene on homologous chromosomes.
homozygous
Having two identical alleles for a gene on homologous chromosomes.
hybridization
Mating of two individuals differing to achieve specific traits in offspring.
incomplete dominance
Expression of two contrasting alleles in a heterozygote resulting in an intermediate phenotype.
law of dominance
In heterozygotes, one trait conceals another for the same characteristic.
law of independent assortment
Alleles segregate independently during gamete formation.
law of segregation
Genes segregate equally into gametes.
linkage
Phenomenon where alleles close together on the same chromosome are inherited together.
model system
Species used to study specific biological phenomena applicable to others.
monohybrid
Cross between two true-breeding parents differing in one characteristic.
P0
Parental generation in a cross.
phenotype
Observable traits expressed by an organism.
product rule
Probability of two independent events occurring simultaneously.
Punnett square
Visual representation of a cross showing possible zygotic genotypes.
recessive
Trait appearing latent when alongside a dominant trait, expressed only in homozygous form.
recessive lethal
Allele lethal only in homozygous form; heterozygote may be normal or altered.
reciprocal cross
Paired cross where respective traits switch between male and female.
sex-linked
Any gene on a sex chromosome.
sum rule
Probability of occurrence of at least one of two mutually exclusive events.