2 - Simplified Pharmacokinetics

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8 Terms

1
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What should be done if both PK & TR are low or high?

dose/measured concentration = new dose/desired concentration

2
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What are the limitations of using desired concentration to find a new dose?

must be at steady-state and collected properly

3
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What should be done if TR is high & PK is low?

  • lengthen interval

  • increase dose


4
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What should be done if TR is low & PK is high?

  • shorten interval

  • decrease dose


5
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How should a new dose be found if TR is high/low & PK is low/high?

dose/(measured PK-TR) = new dose/(desired PK-TR)

6
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How should a new interval be found?

estimate t1/2 from levels, then apply to the new desired dose to determine interval

7
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What should be done if TR is high & PK is normal?

lengthen interval

8
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What should be done if TR is low & PK is normal?

decrease interval