L32- sublingual,buccal, rectal

how do you measure absolute bioavailability in oral drugs when looking at curves

what is the main use of

what is the use of drugs delivered by the mouth buccal and sublingual delivery

they are useful for drugs that treat ulcers fungal infections and periodontal diseases

also useful for drugs that’s are extensively metabolised by the liver as it allows the drug to go directly into the systemic system

what is the main barrier in the mouth for the drug to get through

the epithelium as the drug must go through the stratified squamos epithilium

why is the lining of the mouth where we want the drug to end up

as it is non keratinised ( they don’t have the keratin layer that acts as a barrier )

compare the thickness, permeability and the residence time of buccal and sublingual tissues

thickness- the sublingual is less thicker than the buccal

permeability - the sublingual is more permeable than the buccal

residance time- the buccal is longer than the sublingual

explain the effect of the saliva and the mucus on absobtion via the mouth

they can increase or decrease the absorption of drugs

saliva contains mostly water and some mucus, electrolytes and enzymes

it may hinder the absorption due to saliva wash out- when the saliva pools under the tongue it can wash away the dosage form

the mucus acts as a physical barrier to the drug and is positively charged