Cytokines and Antibodies

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Last updated 3:46 PM on 9/8/26
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19 Terms

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IL-7

Lymphoid lineage commitment (lymphopoesis)

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IFN gamma

Activates macrophages, produced by Th1

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IL-2, IL-15

T cell activation

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IL-17

Neutrophil activation, secreted by Th17

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IL-22

Secreted by Th17, increases barrier function

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IL-10, TGF beta

Immunosuppressive

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IL-1

Inflammatory response, fever

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TNF

Sepsis, fever

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IL-6

Acute phase

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IL-8

Chemokine, neutrophil and monocyte migration

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IFN alpha/beta

Anti-viral

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G-CSF, GM-CSF

Myelopoiesis, granulocyte/monocyte colony stimulating factor

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IL-5

Eosinophil activation, secreted by Th2

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IgM

First produced antibody, activates complement, B cell memory

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IgG

Major antibody, opsonization

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IgE

Allergies, anti-parasite antibody

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IgA

Prevents bacterial colonization, most prevalent at mucosal surfaces, tags for destruction

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IgD

B cell receptor, stimulates release of IgM, least understood antibody

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IL-4, IL-13

Made by Th2, allergic response and anti parasite, IgE production, T cell activation