Cholinergic Agonists AND Antagonists (Block 1 Drugs)

Bethanecol MOA

muscarinic agonist at receptors in bladder

Bethanechol primary indication

treats urinary retention

Bethanechol side effects

cholinergic side effects

Pilocarpine MOA

muscarinic agonist at receptors in eye and salivary glands

Pilocarpine primary indication

treats glaucoma and dry mouth

Pilocarpine side effects

cholinergic side effects

Edrophonium MOA

AChI acting primarily in skeletal muscle

Edrophonium primary indication

treats myasthenia gravis (and diagnostic), reversal agent for NDNMBs

Edrophonium side effects

cholinergic side effects when given in xs (too much Ach around)

Pralidoxime MOA

reactivates AChE (in case of OP poisoning, breaks bond with OP)

Pralidoxime primary indication

treats OP poisoning

Donepezil MOA

AChI acting primarily in CNS

Donepezil primary indication

Alzheimer's

Donepezil side effects

cholinergic side effects

Atropine MOA

muscarinic antagonist at receptors in heart, also acts in other organs to treat OP poisoning

Atropine primary indication

bradycardia, treats parasympathetic symptoms of OP poisoning

Atropine side effects

anticholinergic side effects

Hyoscyamine MOA

muscarinic antagonist at receptors in stomach and lungs

Hyoscyamine primary indication

decreases bronchial and pharyngeal secretions, decreases HCl production to treat peptic ulcer disease

Hyoscyamine side effects

anticholinergic side effects

Scopolamine MOA

muscarinic antagonist at receptors in salivary glands and bronchioles

Scopolamine primary indication

treats drooling

Scopolamine side effects

anticholinergic side effects, patch formulation

Glycopyrolate MOA

muscarinic antagonist in salivary glands

Glycopyrolate primary indication

treats drooling

Glycopyrolate side effects

anticholinergic side effects

Ipratropium MOA

muscarinic antagonist at receptors in lungs

Ipratropium primary indication

treats wheezing in asthma and COPD

Ipratropium side effects

anticholinergic side effects

Oxybutynin MOA

muscarinic antagonist at receptors in bladder

Oxybutynin primary indication

treats urinary incontinence/OVERactive bladder

Oxybutynin side effects

anticholinergic side effects

Pancuronium and Cistracurium MOA

Non-Depo NMBs, competetive antagonist at nicotinic receptors

Pancuronium and Cistracurium primary indication

skeletal muscle relaxation during surgery or mechanical ventilation

Pancuronium and Cistracurium side effects

effects can be reversed by AChI

Succinylcholine MOA

Depo NMB at nicotinic receptors, technically agonist that attaches to Ach receptors causing depolarization BUT xs depo can cause paralysis

Succinylcholine primary indication

skeletal muscle relaxation during surgery or mechanical ventilation

Succinylcholine side effects

effects CAN'T be reversed by AChI