PHAR 507 Exam 2 Structures

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38 Terms

1
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<p>What is this? </p>

What is this?

dopamine

2
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<p>What is this?</p>

What is this?

serotonin

3
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<p>What is this?</p>

What is this?

norepinephrine

4
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<p>What is this?</p>

What is this?

GABA

5
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<p>What drug class is this?</p>

What drug class is this?

MAOI

6
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<p>What drug class is this?</p>

What drug class is this?

MAOI

7
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<p>What drug class if this?</p>

What drug class if this?

MAOI

8
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<p>What drug class is this?</p>

What drug class is this?

MAOI

9
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<p>What drug class is this?</p>

What drug class is this?

MAOI

10
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<p>What drug class is this?</p>

What drug class is this?

MAOI

11
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<p>What drug class is this?</p>

What drug class is this?

TCA (tertiary amine; SERT)

12
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<p>What drug class is this?</p>

What drug class is this?

TCA (both tertiary/secondary)

13
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<p>What drug class is this?</p>

What drug class is this?

TCA (tertiary amine; SERT)

14
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<p>What drug class is this?</p>

What drug class is this?

TCA (tertiary amine; SERT)

15
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<p>What drug class is this?</p>

What drug class is this?

TCA (secondary amine; NET)

16
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<p>What drug class is this?</p>

What drug class is this?

TCA (tertiary amine; SERT)

17
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<p>What drug class is this?</p>

What drug class is this?

TCA (secondary amine; NET)

18
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<p>What drug class is this?</p>

What drug class is this?

TCA (secondary amine; NET)

19
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<p>What drug class is this?</p>

What drug class is this?

TCA (secondary amine; NET)

20
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In tricyclic antidepressants (TCAs), how does adding a methyl (CH₃) branch to the side chain affect transporter affinity?

↓ SERT and NET affinity

21
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In tricyclic antidepressants (TCAs), how do bulky alkyl groups attached to the terminal nitrogen affect drug activity?

Decrease drug activity

22
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In tricyclic antidepressants (TCAs), how does adding a halogen or cyano group at the C3 position of the aromatic ring affect transporter affinity?

↑ SERT affinity

23
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In tricyclic antidepressants (TCAs), what is the optimal side-chain length for transporter binding?

3 carbons

24
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In tricyclic antidepressants (TCAs), which type of alkyl group attached to the terminal nitrogen is preferred for drug activity?

Small alkyl groups

25
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<p>What drug class is this?</p>

What drug class is this?

SSRI

26
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<p>What drug class is this?</p>

What drug class is this?

SSRI

27
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<p>What drug class is this?</p>

What drug class is this?

SSRI

28
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<p>What drug class is this?</p>

What drug class is this?

SSRI

29
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<p>What drug class is this?</p>

What drug class is this?

SSRI

30
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<p>What drug class is this?</p>

What drug class is this?

NARI

31
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<p>What drug class is this?</p>

What drug class is this?

NARI

32
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<p>What drug class is this?</p>

What drug class is this?

SNRI

33
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<p>What drug class is this?</p>

What drug class is this?

SNRI

34
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<p>What drug class is this?</p>

What drug class is this?

SNRI

35
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<p>What drug class is this?</p>

What drug class is this?

SNRI

36
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<p>What drug class is this?</p>

What drug class is this?

Buspirone

37
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<p>What drug class is this?</p>

What drug class is this?

BZD

38
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<p>What drug class is this?</p>

What drug class is this?

Clorazepate (BZD; prodrug)