NBEO- Ocular Embryology (Non Big 8)

Which muscle is NOT derived from mesoderm? (Choose 2)

A) Superior rectus

B) Inferior oblique

C) Iris spincter

D) Iris dilator

C and D (neural ectoderm)

What is the corneal epithelium derived from?

Surface ectoderm

What is the lens derived from?

Surface ectoderm

Which of the following has NO contribution to ocular structures?

A) Mesoderm

B) Ectoderm

C) Endoderm

C (never pick it!!!)

What is the sensory retina derived from?

Neural ectoderm

What is the RPE derived from?

Neural ectoderm

What is the TM, sclera, and choroid derived from?

Neural crest cells

What is the first layer of the retina to develop?

RPE

What is the first sensory retina cell to develop?

A) Amacrine

B) Ganglion

C) Bipolar

D) Muller

B) Ganglion

Place the following terms in order in terms of embryological development. Optic groove, optic vesicle, neural ectoderm

Neural ectoderm --> Optic groove ---> Optic vesicle

Failure of the fetal fissure to close properly results in a ___________.

coloboma

______________ colobomas are the most common due to the location of the embryonic fissure.

A) Inferior

B) Superior

C) Nasal

D) Temporal

A) Inferior

Which of the following is NOT derived from the inner layer of the optic cup?

A) NPCE

B) Anterior iris epithelium of iris

C) Sensory retina

D) Posterior iris epithelium of iris

B) Anterior iris epithelium of iris

The inner layer of the optic cup differentiates into the outer neuroblastic layer and the inner neuroblastic layer. Which three cells are found in the outer neuroblastic layer?

1) Photoreceptors

2) Bipolar cells

3) Horizontal cells

The inner layer of the optic cup differentiates into the outer neuroblastic layer and the inner neuroblastic layer. Which three cells are found in the inner neuroblastic layer?

1) Amacrine cells

2) Muller cells

3) Ganglion cells

The _____________ is the first area of the retina to begin cell differentiation but also the last to fully complete development.

macula

Foveal maturation is not fully complete until approximately which age?

4 years old

Is the RPE or Sensory retina derived from the outer layer of the optic cup?

RPE

_____________ is the most common primary intraocular tumor malignancy in children and is caused by a mutation to the Rb tumor suppressing gene.

Retinoblastoma

Primary lens fibers form the ___________ nucleus of the lens.

embryonic nucleus

Do primary or secondary lens fibers form the fetal nucleus?

Secondary lens fibers

Do anterior lens epithelium or posterior lens epithelium become primary lens fibers?

Posterior lens epithelium

Do anterior lens epithelium or posterior lens epithelium form the fetal nucleus?

Anterior lens epithelium

The Y sutures are from secondary lens fibers that denote the boundaries of the ____________ nucleus of the lens.

Fetal nucleus

Are Y sutures seen within the lens associated with the embryonic or fetal nucleus?

Fetal nucleus

What is the corneal stroma derived from?

Neural crest cells

What is the corneal endothelium derived from?

Neural crest cells

Which ocular structure is NOT derived from surface ectoderm?

A) Corneal epithelium

B) Bowman's layer

C) Conjunctival epithelium

D) Eyelid epithelium

E) Lens

B (neural crest cells)

Meibomian, Zeis, Moll, Krause, and Wolfring glands are all derived from which embryologic tissue?

Surface ectoderm

What is the lacrimal gland derived from?

Surface ectoderm

The lacrimal gland, lacrimal sac, canaliculi, and caruncle is derived from which embryological tissue?

Surface ectoderm

Which epithelium are derived from neural ectoderm? (Choose 2)

A) Corneal epithelium

B) Conjunctival epithelium

C) Iris epithelium

D) Ciliary body epithelium

C and D

Which of the following is NOT derived from neural ectoderm?

A) Optic nerve fibers

B) RPE

C) Sensory retina

D) EOMs

D (mesoderm)

Which of the following is NOT derived from the neural crest cells?

A) Iris epithelium

B) Iris stroma

C) Sclera

D) Choroid

E) Vitreous

A (neural ectoderm)

What is the iris and ciliary body stroma derived from?

Neural crest cells

Axefeld's and Reiger's anomaly are primarily due to abnormal _____________ development.

A) Surface ectoderm

B) Neural ectoderm

C) Neural crest cell

D) Mesoderm

C) Neural crest cell

Fold in Descemet's membrane caused by congenital glaucoma is known as ____________.

Haab's striae

Congenital glaucoma is often characterized by ______________ which is an enlarged eye prior to age 3 secondary to elevated IOP.

buphthalmos

Which of the following is NOT derived from mesoderm?

A) EOMs

B) Endothelium of blood vessels

C) Iris sphincter

D) Levator palpebrae

C (Neural ectoderm)