Metcalf "Understanding Herd Immunity" + Polland "A guide to vaccinology"

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7 Terms

1
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what is the main point in Pollard paper

  • vaccines are made empircally and immunologists are needed to fight hard targets and outbreaks

  • vaccines save 2-3 million lives per year


2
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what’s in a vaccine

  • antigens

  • weakened pathogens


3
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how do vaccines work

  • vaccines protect mainly through antibodies

  • boosters sustain antibody levels


4
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what are the two vaccine requirements for herd immunity

prevent infection and transmission

5
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what is R0

the number of new infections from one case in a fully susceptible population

6
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what does the basic model assume

homogenous mixing and uniform coverage

7
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what is indirect protection

immunization protects more than one person