Kinetics Lec 1

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Last updated 12:50 AM on 10/4/26
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18 Terms

1
New cards

Increase infusion rate, increases

Css

2
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increase clearance decreases

Css

3
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Css is

where you end up

4
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Half life is

how fast you get there

5
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1 half life =

50%

6
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2 half life =

75%

7
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3 half life =

87.5%

8
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4 half lives =

93.75%

9
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5 half lives =

97%

10
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Shorter half life =

faster approach to Css

11
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Longer half life =

slower approach to Css

12
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If Css doubles the time reach

stays the same

13
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Increase or higher Vd =

increase half life and longer time to reach Css

14
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Infusion rate increase then

Css increase

15
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Clearance increases then

Css, half life and time to Css decreases

16
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If Vd increases then

half life and time to Css increases

17
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Increase Vd does what to loading and maintenance dose

increase loading dose but leaves maintenance unchanged

18
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increase clearance does what to loading and maintenance dose

increases maintenance dose but leaves loading unchanged