Phagocyte and Related cells

Neutrophils

Most abundant WBC

First responders to infection

Short lived

Strong at killing bacteria and infection

• Macrophages

• Long lived, develop from monocytes

• Found in tissues(liver, lung,brain)

• Destroy microbes and clear debris

• Present antigens to T-Cells

Monocytes

• Circulating blood cells

• Precursor to macrophages and dendritic cells

• Migrate into tissues and differentiate

• Dendritic cells

• Specialized antigen-presenting phagocytes

• Bridge innate and adaptive immunity

• Less focused on killing, more on activating T cells

Eosinophils

• Limited phagocytosis

• Attack parasites

• Release toxic proteins and enzymes

• Allergy role

Basophils

Release histamine and heparin during allergic/ inflammatory reactions