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tolerance
need more to get the same effect
physical dependence
body adapts; stopping causes withdrawal
withdrawal
symptoms after reducing or stopping drugs
intoxication
behavioral or physical changes from recent use
substance use disorder (SUD)
continued problematic use despite harmful consequences
alcohol withdrawal symptoms 6-12 hr
tremors, anxiety, sweating, insomnia, nausea, tachycardia, hypertension
alcohol withdrawal symptoms 12-24 hr
hallucinosis perceptual disturbances/ hallucinations
alcohol withdrawal symptoms 24-48 hr
seizures generalized/tonic-clonic seizures
alcohol withdrawal symptoms 48-96 ht
delirium tremens (DT's), severe agitation, disorientation, visual hallucinations, fever, marked tachycardia and hypertension. Medical Emergency!!
alcohol withdrawal medication
Benzodiazepines (diazepam/lorazepam) treat alcohol withdrawal
opioid intoxication/OD signs/symptoms
pinpoint pupils, slow breathing, sedation, decrease LOC, hypotension. Priority: airway and breathing
opioid withdrawal signs/symptoms
dilated pupils, yawning, runny nose, tearing, goosebumps, muscle aches, diarrhea
Naloxone (Narcan)
reverses opioid OD and respiration depression, may trigger withdrawal
Methadone
opioid agonist for withdrawals/cravings. Monitor respiration depression, sedation, and QT prolongation
Disulfiram (Antabuse)
causes flushing, nausea/vomiting, palpations, and hypotension if alcohol is consumed
Alprazolam (Xanax)
fast-acting benzodiazepine; may be used for PRN for acute anxiety
benzodiazepine safety: sedation, falls, dependence. avoid alcohol and other CNS depressants; do n
Benzodiazepine safety
sedation, falls, dependence. avoid alcohol and other CNS depressants; do not abruptly stop long-term use
Buspirone
not PRN; takes 1-2 weeks or longer for therapeutic effects; low abuse potential
SSRIs
used for anxiety and OCD; full effect takes weeks
OCD medication trick
SSRIs take 8-12 weeks for full effect in OCD. Do not expect immediate relief
Clomipramine
TCA option for OCD
eustress
positive, motivating stress
distress
negative, overwhelming stress
acute stress
sudden stressor
chronic stress
repeated or prolonged stress
toxic stress
prolonged stress with harmful biological effects
General Adaption Syndrome (GAS)
alarm: fight-or-flight response
resistance: body adapts while still alarmed
exhaustion: stress continues; increases illness risk
regression
returning to previous behavior
repression
unconsciously blocking painful memories
suppression
consciously postpones thoughts
sublimation
channels an urge into a constructive activity (exercises when angry)
acute stress disorder
symptoms from 3 days to 1 month after trauma
PTSD
symptoms lasting longer than 1 month, with distress or impaired functioning
intrusion
flashbacks, nightmares, unwanted memories
arousal/reactivity
Irritability, hypervigilance, and sleep disturbances.
depersonalization
Feeling detached from oneself.
derealization
Feeling that the world is not real/dreamlike
dissociative amnesia
inability to recall important personal information, often related to trauma
anhedonia
loss of interests or pleasures
major depressive disorder
severe symptoms; at least 2 weeks
persistent depressive disorder
depressed mood for 2+ years in adults
premenstrual dysphoric disorder
mood symptoms during luteal phase and resolved with menses
substance/medication-induced depression
associated with use, intoxication, withdrawal
permpartum-onset depression
begins in pregnancy/within 4 weeks postpartum
SSRIs class/must-know
sertraline, fluoxetine: take weeks to work; monitor early treatment for worsening suicidal thoughts/serotonin syndrome
SNRIs
venlafaxine, duloxetine: monitor BP (venlafaxine); do not stop abruptly
TCAs
amitriptyline, desipramine: dry mouth, constipation, urinary retention, orthostatic hypotension, cardiac toxicity in OD
MAOIs
phenelzine: avoid tyramine-rich foods: risk of hypertensive crisis
lithium
maintain consistent Na+ and fluid intake; monitor blood levels and toxicity
Risperidone
monitor weight, glucose, lipids, EPS, tardive dyskinesia, and neuroleptic malignant syndrome
diphenhydramine
can treat acne dystonia/EPS, may cause sedation and anticholinergic effects
What is the therapeutic range for lithium levels?
0.6-1.2 mEq/L
What lithium level is considered toxic?
>1.5 mEq/L
What are some symptoms of lithium toxicity?
Course tremor, vomiting, diarrhea, confusion, ataxia
What factors can increase the risk of lithium toxicity?
Dehydration and NSAIDs
What does lithium prefer in terms of consistency?
Fluids, sodium (Na+), and regular blood level monitoring
serotonin syndrome
life-threatening reaction from excessive serotonin activity
serotonin syndrome symptoms
Neuro: tremors, hyperreflexia, clonus, rigidity, ataxia
Autonomic: sweating, tachycardia, hypertension, hyperthermia, diarrhea
Mental Status: agitation, restlessness, confusion
MAIOs food interactions
avoid tyrone-rich: aged cheese, cured/processed meats, tab beer, red wine, soy sauce, fermented foods
flight of ideas speech
rapidly changes topics (topics fly by)
tangential speech
goes off-topic, never returns to point (takes a tangent)
circumstantial speech
excessive details and eventually answers (circles before arriving)
loose associations
illogical shifts between topics (connections loose)
word salad
nonsensical, disorganized responses
clanging
words linked by rhyme or sound (clang = sound)
neologisms
makes up new words
thought blocking
speech suddenly stops (thought and speech blocked off)
poverty of speech
limited speech content; few words
grandiose delusion
believing they have extreme importance or power
persecutory delusion
believing they are being followed, watched, or targeted
jealousy delusion
believing their partner is unfaithful
religious delusion
believing they have special status with God
somatic delusion
believing they have a physical defect or illness that is not present
ideas of reference delusion
events or environmental messages are specifically about them
thought insertion delusion
believing someone is putting thoughts into their head
thought broadcasting delusion
believing their thoughts are being broadcasted to others