Advanced Biochemistry Final Exam

subunit of eIF2A's GEF that is bound tightly by PERK's phosphorylated product

eIF2Balpha

target of ULK1 kinase activity

ATG14

most common amino acid of signal peptides

leucine

inhibits ULKs autophagy signaling

mTORC1

binds to the CBS domains of AMPK to enable activation

AMP

redundant single protein containing both domains required for reinitiation of translation that are also found in the heterodimeric reinitation complex

eIF2D

activates ULK1's autophagy signaling

AMPK

heterdimeric complex directly associated with reinitiation sequences such as found on the ATF4 mRNA

DENR/MCLTS1

subunit which binds to GTP and forms hydrophobic association with signal peptide emerging from the ribosome

SRP 54

stabilizes the association of Met-initiator tRNA with AUG

eIF1

guanosine binding subunit of eIF2

eIF2Agamma

Activates AMPK at T-172

LKB1

molecule with extended structure that allows both signal peptide recognition and inhibition of aminoacyl-tRNA entry into the A site

SRP-mRNA

low leucine enhances stalling and reinitiation of the ribosome at CUUCUC found at the beginning of \____ coding sequence

ORF2

GEF subunit for eIF2

eIF2Bepsilon

encoded peptide n-MAY-COO- is produced by the essential mammalian \____ for reinitiation on the ATF4

ORF1

protein produced in response to ATF4 transcriptional activation most responsible for relieving unfolding stress at the rER

BiP/GRP78

portion of ATF4 mRNA that encodes ATF4

ORF3

when eIF2A/GTP levels are high, the major large protein produced is encoded by \____ of the ATF4 mRNA

ORF2

target of PERK that slows translational initiation globally within the cell

eIF2Aalpha

during GEF action, eIF2Aalpha binds directly to

eIF2Bgamma