drug - gene pairs (pharmacogenomics)

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31 Terms

1
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where does genetic polymorphism affect PK

absorption

metabolism

2
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phenytoin

CYP2C9

HLA-B*12:02

3
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warfarin

CYP2C9

CYP4F2

VKORC1

4
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NSAIDs

CYP2C9

5
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citalopram/escitalopram

CYP2C19

6
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TCAs

CYP2C19

CYP2D6

7
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clopidogrel

CYP2C19

8
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PPIs

CYP2C19

9
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voriconazole

CYP2C19

10
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paroxetine

CYP2D6

11
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fluvoxamine

CYP2D6

12
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vortioxetine

CYP2D6

13
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venlafaxine

CYP2D6

14
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atomoxetine

CYP2D6

15
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codeine/tramadol/hydrocodone

CYP2D6

16
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ondansetron

CYP2D6

17
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tamoxifen

CYP2D6

18
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sertraline

CYP2B6

19
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tacrolimus

CYP3A5

20
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capecitabine/fluorouracil/tegafur

DPYD

21
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thiopurines

TPMT

NUDT15

22
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statins

SLCO1B1

23
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atazanavir

UGT1A1

24
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abacavir

HLA-B*57:01

25
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rasburicase

G6PD

26
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allopurinol

HLA-B*58:01

27
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oxcarbazepine

HLA-A*15:02

28
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carbamazepine

HLA-A*31:01

HLA-B*15:02

29
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ivacaftor

G551D

30
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anti-EGFR mAb

RAS

31
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irinotecan

UGT1A1