sodium-glucose cotransporter 2 (SGLT2) inhibitor

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9 Terms

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SGLT2 inhibitor drug

canagliflozin (Invokana)

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Indication of SGLT2 inhibitor

Type 2 diabetes mellitus

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Mechanism of SGLT2 inhibitor

Inhibits SGLT2 in the proximal renal tubules, reducing
reabsorption of filtered glucose from the tubular
lumen

Inhibits glucose resorption in the distal tubule of nephron

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Black Box Warnings of SGLT2 inhibitor

none

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Contraindications of SGLT2 inhibitor

Severe renal impairment (ESRD, dialysis); Serious hypersensitivity (eg, anaphylaxis, angioedema)

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Common adr of SGLT2 inhibitor

Urinary tract infection, hypotension, hyperkalemia, dehydration, genitourinary fungal infections

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rare adr of SGLT2 inhibitor

Euglycemic ketoacidosis, acute renal failure, bone fracture, perineal necrotizing fasciitis, Risk of lower limb amputations

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Counseling points of SGLT2 inhibitor

Take before breakfast daily. Ensure adequate hydration on the drug and adequate genital
hygiene

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Other drugs in class SGLT2 inhibitor

Dapagliflozin (Farxiga), Empagliflozin (Jardiance), Ertugliflozin (Steglatro), Bexagliflozin (Brenzavvy)