Endocrine Pancreas

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8 Terms

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What is the pancreas mostly composed of?

Exocrine glands (99%), with a bit of endocrine cells (1%)

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Islets of Langerhans

Endocrine cells in pancreas

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What cells are in islets of Langerhans?

Alpha cells, beta cells, delta cells, PP cells

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Alpha cells

Produce glucagon, stimulating hepatocytes and beta cells to make insulin through paracrine communication

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Beta cells

Produce insulin, stimulating adipocytes and skeletal muscle myocytes, inhibits alpha cells

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Delta cells

Produce somatostatin, inhibiting alpha and beta cells

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PP cells

Produce pancreatic polypeptide, which stimulates exocrine pancreatic acinar cells

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Causes of T1DM

Decreased plasma insulin due to autoimmunity to pancreatic beta cells