Adverse Effects + Unique Drug PEARLS for BH

SSRIs, SNRIs

Fluvoxamine

nausea, diarrhea (SSRI)

Fluoxetine

agitation, insomnia, anorexia (SSRI)

Paroxetine

sedation, increased appetite, weight gain (SSRI)

Sertraline

Diarrhea; GI Disturbances (SSRI)

Citalopram

QT prolongation (high dose); Headache (SSRI)

Unique SSRI adverse effects

Sexual dysfunction, hyponatremia, Abnormal bleeding, discontinuation symptoms

SSRI with Drug Interactions

Fluoxetine, Paroxetine, Fluvoxamine

Increased risk of fetal cardiac malformation with this SSRI:

Paroxetine

Which SNRI had greater serotonergic activities at lower dose

Venlafaxeine (Desvenlafaxine)

Treats depression and pain (SNRI)

Duloxetine

SNRI only approved for fibromyalgia

Milnacipran

SNRI General adverse effects

GI effects, sexual dysfunction, discontinuation symptoms

Venlafaxine

Hypertension, Tachycardia (higher dose) (SNRI)

Duloxetine

Hepatotoxicity (SNRI)

Drug Interactions meds of SNRIs

Duloxetine, Venlafaxine, Desvenlafaxine

TCAs antagonize these receptors

Alpha-1 adrenergic, Histamine H1, Muscarinic

Which TCA can be used in low dose for insomina

Doxepin

TCA Adverse Effects

Anticholinergic (dry mouth, constipation, urinary retention), Sedation, Weight gain, Orthostatic hypotension, tachycardia

TCA overdose effects

Cardiovascular effects (QRS widening), seizures, CNS depression