Oncogenes/Tumor Suppressor Genes

ALK and EGFR (ERBB1) (Receptor tyrosine kinase)

Oncogenes associated with lung adenocarcinoma.

HER2 (ERBB2) (Receptor tyrosine kinase)

Oncogene associated with breast carcinoma and gastric carcinoma.

RET (Receptor tyrosine kinase)

Oncogene associated with MEN2A and 2B, medullary and papillary thyroid carcinoma, and pheochromocytoma.

BCR-ABL (Non-receptor tyrosine kinase)

Oncogene associated with CML and ALL.

JAK2 (Non-receptor tyrosine kinase)

Oncogene associated with myeloproliferative neoplasms.

BRAF (Serine/threonine kinase)

Oncogene associated with melanoma, Non-Hodgkin lymphoma, papillary thyroid carcinoma, and Hairy cell leukemia.

c-KIT (CytoKIne receptor CD117)

Oncogene associated with gastrointestinal stromal tumor (GIST) and mastocytosis.

MYCC (c-myc) (Transcription factor)

Oncogene associated with burkitt lymphoma.

MYCN (N-myc) (Transcription factor)

Oncogene associated with neuroblastoma.

MYCL1 (Transcription factor)

Oncogene associated with lung tumor (small cell).

KRAS (RAS GTPase)

Oncogene associated with colorectal cancer, lung cancer, and pancreatic cancer.

BCL-2 (Anti-apoptotic molecule)

Oncogene associated with follicular and diffuse large B cell lymphomas.

APC

Tumor suppressor gene associated with colorectal cancer, and familial adenomatous polyposis. First step in the classic adenoma-to-carcinoma sequence.

BRCA1/BRCA2

Tumor suppressor gene associated with breast cancer, ovarian cancer and pancreatic cancer.

CDKN2A (Cyclin Dependent Kinase)

Tumor suppressor gene associated with melanoma, lung cancer, and pancreactic cancer.

DCC

Tumor suppressor gene associated with colorectal cancer.

SMAD4 (DPC4)

Tumor suppressor gene associated with pancreatic and colorectal cancer.

MEN1

Tumor suppressor gene associated with multiple endocrine neoplasia 1.

NF1 (Chr 17)

Tumor suppressor gene associated with neurofibromatosis 1.

NF2

Tumor suppressor gene associated with neurofibromatosis 2.

PTEN

Tumor suppressor gene associated with prostate cancer, breast cancer, and endometrial cancer.

RB1

Tumor suppressor gene associated with retinoblastoma and osteocarcinoma.

TP53

Tumor suppressor gene associated with majority of spontaneous (acquired) cancers, final mutation in the adenoma-carcinoma sequence, and Li-Fraumeni syndrome (inherited): multiple malignancies at an early age: sarcoma, breast/brain, lung/leukemia, adrenal gland.

TSC1 (hamartin protein) and TSC2 (tuberin protein)

Tumor suppressor genes associated with tuberous sclerosis.

VHL

Tumor suppressor gene associated with Von Hippel-Lindau disease: High risk of bilateral renal cell carcinomas, cerebellar hemangioblastomas, retinal hemangiomas, liver cysts.

WT1 (Transcription factor)

Tumor suppressor gene associated with Wilms tumor.