Adrenergic Agonists AND Antagonists (Block 1 drugs)

NE primary aciton

a-1 agonist

Epi primary action(s)

B-1 and B-2 agonist

NE mechanism

-> a-1 agonist -> vasoCONSTRICT -> increase PR -> increase BP -> baroreceptors cause reflex bradycardia

Epi B-1 mechanism

-> B-1 agonist -> heart -> increase HR

Epi B-2 mechanism

-> B-2 agonist -> BV -> vasoDILATE BV -> decrease PR

Epi mechanisms summary

B-1 agonism: increase HR and increase systolic BP

B-2 agonism: BV vasodilation and decrease diastolic BP

NE MOA

a-1 agonist

NE primary indication

treats hypOtension and shock (hypotension not responsive to dopamine)

NE side effects

reflex BRADYcardia (baroreceptors)

Epi MOA

a-1 agonist, B-1 agonist, B-2 agonist

Epi primary indication

treats anaphylaxis, cardiac arrest, and ventricular fibrillation

Epi side effects; LOW doses

increase stimulation of B-2 over a-1 receptors decreases diastolic BP

Epi side effects; HIGH doses

increase vasoCONSTRICTion effects in a-1 receptors, increases diastolic AND systolic BP

Dopamine MOA

a-1 agonist, B-1 agonist, D-1 agonist (also acts on D-1 receptors in kidneys to increase renal blood flow)

Dopamine effect on D-1 receptors in kidneys

increases renal blood flow

Dopamine primary indication

treats cardiogenic shock

Isoproterenol MOA

B-1 agonist, B-2 agonist

Isoproterenol primary indication

treats AV block and bradycardia

Phenylephrine MOA

a-1 agonist

Phenylephrine primary indication

nasal decongestion

Midodrine MOA

a-1 agonist

Midodrine primary indication

orthostatic hypOtension

Albuterol MOA

B-2 agonist

Albuterol primary indication

treats asthma

Albuterol side effects

SHORT acting (SABA)

Salmeterol MOA

B-2 agonist

Salmeterol primary indication

treats asthma

Salmeterol side effects

LONG acting (LABA)

Clonidine MOA

activate a-2 receptors in CNS -> decreases sympathetic outflow to heart and vascular smooth muscle

Clonidine primary indication

treats HTN and anxiety

Cocaine MOA

block reuptake of NE and Dopamine

Amphetamine MOA

increase release of NE in PNS and CNS

Amphetamine primary indication

treats ADHD and narcolepsy

Amphetamine side effects

increase HR and BP

Metyrosine MOA

inhibits NE synthesis

Metyrosine primary indication

pheochromocytoma (adrenal gland tumor)

Mirabegron MOA

B-3 receptor agonist

Mirabegron primary indication

treats OVERactive bladder

Phenoxybenzamine MOA

Non-competetive a-1 AND a-2 antagonist

Phenoxybenzamine primary indication

HTN in pheochromocytoma

Phentolamine MOA

competetive a-1 AND a-2 antagonist

Phentolamine primary indication

HTN in pheochromocytoma

Phentolamine side effects

reflex TACHYcardia due to blockade of pre-synaptic a-2 receptors

Doxazosin MOA

a-1 antagonist

Doxazosin primary indication

treats BPH by relaxing bladder and prostatic smooth muscle

Atenolol MOA

B-1 antagonist/blocker

Atenolol primary indication

HTN, angina, acute MI

Metoprolol MOA

B-1 antagonist/blocker

Metoprolol primary indication

HTN, angina, acute MI

Carvedilol MOA

B-1 antagonist, B-2 antagonist, a-1 antagonist

Carvedilol primary indication

HTN and heart failure

Labetalol MOA

B-1 antagonist, B-2 antagonist, a-1 antagonist

Labetalol primary indication

HTN