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Neurons
the building blocks of the nervous system -> about 100 billion
Dendrites
branch-like projections that receive messages from other neurons and send them to the neuron
Soma
(cell body) structure made up of a nucleus that determines when the neuron has reached the threshold to fire
- also carries out basic metabolic functions of neurons
Axon
the "tail" of the neuron along which electrical signals are conducted
- passes messages away from cell body to other neurons, muscles or glands
Action Potentials
the electrical signals created by Axon -> carry messages to neutrons
- neuron is depolarized -> positive inside of cell for a moment
Myelin Sheath
white fatty substance that wraps axons -> insulates the axon and inscreases the speed ofthe action potential causing faster communication
-deterioration leads to motor/cognitive impairments
Nodes of Ranvier
notches in between myelin that allow exchange of sodium and potassium
Axon Terminals
knobs at the end of each axon that house chemical messengers called neurotransmitters (terminal buttons)
Synapse
the microscopic gap between terminal buttons of the presynaptic (sending) neuron and the dendrites of the postsynaptic (receiving) neuron
Glial cells
support cells that hold together the message - sending neurons and support their functioning -> provide nutrients
-"glue" neurons in place, form myelin around axons
Resting state
when a neuron is in resting state -> it has a slight negative charge due to presence of potassium ions
- it is positive outside of resting state
Firing threshold
the minimum level of membrane depolarization for a neuron or muscle cell to generate action potential
- level necessary for neuron to fire
Depolarization
positively charged sodium ions rush into the cell and potassium ions flow out temporarily leaving cell positively charged on inside
All-or-none response
a neuron can never fire "harder" or "stronger" because it either fires completely or not at all
Refractory period
the cell cannot fire again -> very brief (rest period)
- process of repolarization
Repolarization
each section of the axon needs to "push out" the positive sodium ions so the overall charge of the cell becomes negative again
Neurotransmitters
chemicals that allow for communication between neurons
- travel across synapes to bind to receptor sites
Vesicles (sacs)
sacs of terminal buttons (axon transmitters) at the end of the axon
Postsynaptic neuron
a nerve cell that receives neurons from another neuron (presynaptic)
Reuptake
the absorption by a presynaptic nerve ending of a neurotransmitter that it has secreted
Antagonist
dugs that inhibit or impede the action of a neurotransmitter
Agonist
drugs that inhace or amplify the action of a neurotransmitter
Lock and key
a specific neurotransmitter (key) binds only to its corresponding receptor protein (lock) on a postsynaptic neuron
Excitatory signal
excitatory neurotransmitter signals trigger action
- like a gas pedal
Inhibitory signal
inhibitory neurotransmitter signals depress action
- break pedals
Substance P
sends pain messages
- P is for pain "substance pain"
Serotonin
impacts mood, sleep, and appetite
- too much = maybe autism and anxiety
- too little = depression, OCD and eds
se"rot"onin -> rotten mood
Norepinephrine
involved in alertness and arousal of flight/fight - helps breathing, stimulates heart rate and constricts blood vessels
- too much = anxiety and panic attacks
- too little = depression
"Epi-pen"
Acetylcholine (ACH)
enables muscle action, influences memory-linked to alzheimers
"in order to hit an ACE in tennis you need good muscle control"
GABA
primary inhibitory neurotransmitter in the brain
- too little = insomnia
- too much = seizures
"Get A Brake Adjustment"
Glutamate
primary excitatory neurotransmitter in the brain
too much = seizures and migranes
"you get excited when you're glued to your mate"
Endorphins
block pain messages and linked to pleasure
- opiates are essentially artificial endorphins
ENDURE pain
Dopamine
associated with pleasurable emotions, reward pathways, learning and attention and movement
too little = Parkinson's disease
too much = schizophrena
"Dopey on Dopamine"