complement proteins + effects of deficiency

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9 Terms

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C1, C2, C4

immune-complex disease

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C3

susceptibility to encapsulated bacteria

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C5-C9

susceptibility to Neisseria

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Factor D, prosperdin (factor P)

susceptibility to encapsulated bacteria & Neisseria but no immune-complex disease

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Factor I

similar effects to deficiency of C3 (susceptibility to encapsulated bacteria)

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MCP, factor I or factor H

Atypical hemolytic-uremic syndrome (aHUS)

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polymorphisms in factor H

age-related macular degenerationq

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DAF, CD59

autoimmune-like conditions, including paroxysmal nocturnal hemoglobinuria

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C1INH

hereditary angiodema (HAE)