Chapter 7 kreb cycle

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10 Terms

1
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what is the job of the kreb cycle?

to strip high energy electrons from Acetyl-coA and load them onto NADH and FADH2 so they can make their way to ETC

2
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first step of Krebs cycle + enzyme

the 2-carbon Acetyl-coA combines with 4-carbon Oxaloacetate (which is already present in cycle) to form a 6-carbon molecule called Citrate. coA is released

enzyme used is citrate synthase

<p>the 2-carbon Acetyl-coA combines with 4-carbon Oxaloacetate (which is already present in cycle) to form a 6-carbon molecule called Citrate. coA is released </p><p>enzyme used is <strong>citrate synthase</strong></p>
3
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2nd step of krebs cycle + enzyme

Citrate is rearranged into Isocitrate

enzyme is Aconitase

<p>Citrate is rearranged into Isocitrate </p><p>enzyme is <strong>Aconitase</strong></p>
4
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3rd step of kreb cycle + enzyme

isocitrate is oxidized

  • one carbon is removed as co2

  • NADH formed

isocitrate becomes the 5 carbon molecule a-ketoglutarate

enzyme is Isocitrate dehydrogenase

<p>isocitrate is oxidized</p><ul><li><p>one carbon is removed as co2</p></li><li><p>NADH formed </p></li></ul><p>isocitrate becomes the 5 carbon molecule a-ketoglutarate</p><p>enzyme is<strong> Isocitrate dehydrogenase</strong></p>
5
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4th step of krebs cycle + enzyme

a-ketoglutarate is oxidized and becomes Succinyl-coA

NADH formed

enzyme is a-ketoglutarate dehydrogenase

<p>a-ketoglutarate is oxidized and becomes Succinyl-coA</p><p>NADH formed </p><p>enzyme is<strong> a-ketoglutarate dehydrogenase</strong></p>
6
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5th step of krebs cycle + enzyme

Succinyl coA - with high energy bond bc of coA - breaks the bond releasing lots of energy. the energy makes GTP / ATP. the coA is removed forming succinate.

enzyme is SuccinylcoA-sythetase

<p>Succinyl coA - with high energy bond bc of coA - breaks the bond releasing lots of energy. the energy makes GTP / ATP. the coA is removed forming succinate. </p><p>enzyme is<strong> SuccinylcoA-sythetase</strong></p>
7
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6th step of krebs cycle + enzyme

succinate is oxidized but this time FADH2 is the acceptor.

succinate → Fumurate

enzyme is Succinate dehydrogenase

<p>succinate is oxidized but this time FADH2 is the acceptor.</p><p>succinate → Fumurate</p><p>enzyme is Succinate dehydrogenase</p>
8
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7th step of krebs cycle + enzyme

water is added to fumarate

  • fumarate + H2o → Malate

enzyme is fumarase

<p>water is added to fumarate </p><ul><li><p>fumarate + H2o → Malate </p></li></ul><p>enzyme is <strong>fumarase</strong> </p>
9
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8th and final step of krebs cycle + enzyme

malate is oxidized which regenerates oxaloacetate and cycle restarts

NADH formed

enzyme is malate dehydrogenase

<p>malate is oxidized which regenerates oxaloacetate and cycle restarts</p><p>NADH formed</p><p>enzyme is <strong>malate dehydrogenase</strong></p>
10
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what does Krebs cycle produce?

results for 2 Acetyl coA:

6NADH

2FADH2

2ATP