Dengue

Arbovirus

Spreads by arthropods such as mosquitoes

Transmission

Human → mosquito → human

Reservoir

Maintained primarily in humans, mosquitoes are VECTORS rather than reservoirs

Dengue cases

50 million cases annually worldwide

symptoms

fever, joint pain, rash, muscle aches

severe dengue

hemorrhagic fever/dengue shock syndrome

dengue hemorrhagic fever

severe disease associated with bleeding/hemorrhagic manifestations

Dengue shock syndrome

involves low blood pressure & clinical signs of shock

severe dengue platelet count

low platelets

asymptomatic dengue

approximately 50-200 million asymptomatic infections/year

Dengue control

mosquito control, insecticide, larvicide, adulticide, reducing stagnant water, biological control (Wolbachia)

Pediatric Dengue

disease & death are highest among children under 15

dengue serotypes

increased circulation/spread of all 4 serotypes may contribute to increased disease severity

Dengue asymptomatic children

cohort studies found >50% of children did not report symptoms