resistant drugs

Minimum inhibitory concentration

min amount of drug in the sys to be effective : much more narrow therapeutic index

Post-antibiotic effect

term that is sued to treat resistance organism ; can have continued therapeutic effect even after the antibiotic has stopped --> can benefical

Synergistic effect

exponential effects with drug

Therapeutic drug monitoring

peak level and trough level

what drugs need to be watched with cautious

vacomycin and erthyomycin

Peak

one hour after giving

trough

one hour before next dose

Time dependent killing

means the antibiotic works best when the bacteria are exposed to the drug for a longer amount of time, rather than when you give one huge dose.

what are other options for esbl

Tigecycline and colistimethate

classes for drug resistant organisms

Aminoglycosides

Quinolones

Miscellaneous antibiotics

prototype for aminoglysides

micin drugs

prototypes for quinolones

ciprofloxacin

mrsa drug class type

bacteriacidal

aminoglysides indications

g- and g+ bacteria

heptic encelphaopthy

pre op prep

contra indications of amino

pregnancy D

adverse effects of amino

otoxicity

nephrontocivity

gentamicin route

parental

neomicin route

oral

rectal

topical

quinolones indication

complicated infections

stis

anthrax

contraindication of quinolones

prepubscent children except w cystic firbrosis

mnemonic for quinolones interactions

AAIDS

AAIDS

antidysrhytmic

antacid

iron

dairy

sucralfate

cardiac ae for quinolones

prolonged qt intervals

ae of quinolones

tendonitis

neuopathy

miscellanous antibiotic

metronidazole

vancomyxcin

metronidzale indication

intraabdominal gynecologic and protozoal infections

contraindications od metronidazole

1st trimester of pregnancy

caution of metronidazole

hx of alc abuse

adv effects of metronidazole

reversible neutropenia and thrombocytopenia

interections of metronidazole

Alcohol (24 hr pre – 36 hr post)

CYP450

vancomycin indication

mrsa

vancomycin is reserved for

resistant infection

caution of vancomycin

renal dysfunction

hearing loss

elderly

neonates

ae of vancomycin

ototoxicity

neprotoxicity

red man syndrome

MOINTOR SERUM DRUG LEVELS

what should u monitor with vancomycin

bun

creatin

gfr

how would u administer vancomycin

iv piggy back

treatment of red man syndrome

slow infusion (at least one hour)

when shoulg u give quinolines

1 hour before or after meals