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growth hormone
anterior pituitary gland
too much is acromegaly too little would result in dwarfism
antidiuretic hormone ADH
posterior pituitary gland
too much results in weight gain too little dilute urine
parathyroid hormone
parathyriod is the source gland.
too much results in hyperthyroidism
too little hypocalcemia
insulin
beta cell in pancreatic
too much results in hypoglycemia; too little leads to hyperglycemia.
thyroid
largest endocrine gland
dual role organ and its two job
pancrease
Hyperparathyroidism
Bones lose calcium because calcium is released into the blood.
Hypoparathyroidism:
Low calcium can cause tingling, muscle cramps, spasms, and tetany.
Insulin
lowers blood glucose by helping glucose move from the bloodstream into cells.
Too much insulin =
Hypoglycemia (low blood sugar)
Too little insulin or ineffective insulin =
Hyperglycemia (high blood sugar
The pancreas has two jobs:
Endocrine function: Releases insulin and glucagon into the bloodstream to regulate blood sugar.
• • Exocrine function: Releases digestive enzymes through ducts into the small intestine to help digest food.
Type 1 Diabetes
Autoimmune disease.
The immune system attacks and destroys insulin-producing beta cells in the pancreas.
The body produces little to no insulin.
Usually develops earlier in life, but can occur at any age.
Requires insulin therapy.
Key term: Absolute insulin deficiency.
Type 2 Diabetes
The body develops insulin resistance.
Cells do not respond properly to insulin.
The pancreas may initially produce more insulin, but eventually cannot keep up with the body’s needs.
Often associated with genetics, excess body weight, and physical inactivity.
Managed through lifestyle changes, medications, and sometimes insulin.
Key term: Insulin resistance.
Insulin resistance:
Body cells do not respond properly to insulin.
Hyperglycemia:
Abnormally high blood glucose.
Hypoglycemia:
Abnormally low blood glucose.
Polyuria:
Excessive urination.
Polydipsia:
Excessive thirst.
Polyphagia:
Excessive hunger.
Both Type 1 and Type 2 can cause the three
Ps:
Polyuria
Polydipsia
• • Polyphagia
DKA
Diabetic Ketoacidosis.It is a serious complication that occurs when the body does not have enough insulin and begins breaking down fat for energy.
Insulin deficiency – not enough insulin is available.
Step 1
Glucose cannot enter cells effectively.
step 2
Blood glucose rises (hyperglycemia).
step 3
Kidneys remove excess glucose through urine, causing osmotic diuresis.
step 4
Excessive urination causes dehydration and electrolyte loss.
step 5
The body breaks down fat for energy, producing ketones.
step 6
ketones build up, causeing metabolic acidosis
step 7
DKA signs and symptoms
Fruity-smelling breath.
Nausea and vomiting.
Abdominal pain.
Excessive thirst.
Frequent urination.
Dehydration.
Deep, rapid breathing (Kussmaul respirations).
Confusion in severe cases.
Key term: Kussmaul respirations
Deep, rapid breathing that helps the body eliminate carbon dioxide to compensate for metabolic acidosis.
What causes LOW blood glucose?
taking too much insulin.
Taking too much diabetes medication that lowers glucose.
Skipping or delaying a meal.
Not eating enough carbohydrates.
Exercising more than usual without adjusting food or medication.
• • Drinking alcohol without adequate food.
Diabetic neuropathy
is nerve damage caused by prolonged high blood glucose.
Sensory (Peripheral) Neuropathy
sensory nerves, especially in the feet and legs.
Signs and symptoms:
Numbness.
Tingling (pins and needles).
Burning pain.
Loss of sensation.
Reduced ability to feel temperature or pain.
Functional consequences:
Increased fall risk.
Cannot feel injuries to feet.
Increased risk of foot ulcers and infections.
Difficulty with balance and walking.
PTA tip: Always check the feet for wounds and skin breakdown because the patient may not feel an injury.
Motor Neuropathy
Motor nerves that control muscles.
Signs and symptoms:
Muscle weakness.
Muscle wasting (atrophy).
Decreased muscle control.
Foot deformities.
Foot drop.
Functional consequences:
Difficulty walking.
Abnormal gait.
Poor balance.
Increased fall risk.
Difficulty with transfers.
PTA tip: Assess strength, gait, balance, and functional mobility.
autonomic neuropathy
Autonomic nerves that control involuntary body functions.
These include:
Heart rate.
Blood pressure.
Digestion.
Bladder function.
Sweating.
Signs and symptoms:
Orthostatic hypotension (blood pressure drops when standing).
Dizziness.
Gastroparesis (delayed stomach emptying).
Bladder dysfunction.
Abnormal sweating.
Sexual dysfunction.
Functional consequences:
Dizziness or fainting when standing.
Increased fall risk.
Digestive problems.
Difficulty regulating body temperature.
PTA tip: Monitor blood pressure and watch for dizziness when moving a patient from sitting to standing.
Diabetic retinopathy (what is damaged)
A diabetes-related eye disease that affects the retina, leading to vision impairment. It results from damage to the blood vessels in the retina, causing them to leak fluid or bleed.
diabetic neuropathy (what is damaged)
kidneys
Peripheral neuropathy (what is damaged)
Peripheral nerves
Cardiovascular disease (what is damaged)
♡ and blood vessels, leading to reduced blood flow.
Peripheral artery disease (PAD)
Blood circulation to extremities
Diabetic foot ulcers what is affected
skin and tissue of feet
Diabetes damages the:
Eyes
Kidneys
Nerves
Heart
• • Feet
Open compound
fracture where the bone pierces the skin
closed (simple)
fracture where the bone does not pierce the skin
Comminuted
fracture where the bone is shattered into multiple pieces
Impacted
Push one broken end into another, causing them to compress together.
Greenstick
fracture where the bone bends and cracks on one side (partial fracture) without breaking completely through. typically in children
Compression
is a fracture caused by excessive force that crushes the bone, often seen in vertebrae.
Pathological
fracture occurring in a bone weakened by disease or condition, rather than due to high impact or stress.
sprain
tear in ligament
strain
muscle and tendon tear
avulsion injury
ligament or tendon completely separates
osgood schlatter syndrome
painful form of tendonitis
fibromyalgia
specific tender points for pain that can result in widespread muscle discomfort. It is characterized by chronic pain, fatigue, and sleep disturbances.
apnea
temporary cessation of breathing during sleep.
tachypnea
abnormally rapid breathing rate, often seen in response to stress or illness.
hyperpnea
increased depth and rate of breathing, typically occurring in response to exercise or metabolic demands.
dyspnea
difficult or labored breathing, often associated with underlying health conditions.
orthopnea
difficulty breathing when lying flat, typically relieved by sitting or standing.
hemoptysis
coughing up blood or blood-stained sputum, often indicative of a respiratory condition.
cyannosis
a bluish discoloration of the skin and mucous membranes due to inadequate oxygenation of the blood.
hypercapnia
an increased level of carbon dioxide in the blood, often leading to respiratory acidosis.
hypoxemia
a deficiency of oxygen in the blood, which can lead to symptoms like confusion, shortness of breath, and cyanosis.
tidal volume
the amount of air inhaled or exhaled during normal breathing. 500 ml
Inspiratory reserve volume
the maximum amount of air that can be inhaled after a normal tidal volume inhalation, typically around 3000 ml.
expiratory reserve volume
the maximum amount of air that can be exhaled after a normal tidal volume exhalation, usually about 1100 ml.
residual volume
the amount of air remaining in the lungs after a maximal exhalation, typically around 1200 ml.
vital capacity
the total amount of air that can be exhaled after a maximal inhalation, which includes tidal volume, inspiratory reserve volume, and expiratory reserve volume; typically around 4800 ml.
total lung capacity
is the maximum amount of air that the lungs can hold, calculated as the sum of vital capacity and residual volume, typically around 6000 ml.
asthma
a chronic respiratory condition characterized by inflammation and narrowing of the airways, resulting in wheezing, coughing, shortness of breath, and tightness in the chest.
acute bronchitis
is an inflammation of the bronchial tubes, often caused by viral infections, leading to coughing, mucus production, and difficulty breathing. It usually resolves after a few weeks.
chronic bronchitis
is a long-term inflammation of the bronchial tubes, often due to smoking or prolonged exposure to irritants, characterized by persistent cough and mucus production.
emphysema
is a progressive lung disease that destroys the air sacs in the lungs, leading to shortness of breath and reduced oxygen exchange. It is commonly caused by smoking and long-term exposure to airborne irritants.
COPD
is a group of lung diseases that obstruct airflow and make it difficult to breathe, primarily including chronic bronchitis and emphysema.
Cystic Fibrosis
is a genetic disorder that affects the lungs and digestive system, causing severe respiratory problems and digestion issues due to thick, sticky mucus production.
pneumothorax
is a condition where air leaks into the space between the lungs and chest wall, causing lung collapse and difficulty breathing. It can result from trauma, certain medical procedures, or lung disease.
pulmonary edema
is a condition characterized by excess fluid in the lungs, leading to impaired gas exchange and difficulty in breathing.
aspiration
occurs when food, liquid, or other substances enter the airway and lungs instead of the esophagus, which can lead to choking, infection, or pneumonia.
pleural effusion
is the accumulation of excess fluid in the pleural space surrounding the lungs, which can cause difficulty breathing and chest pain.