Pharmacology II Exam I drugs

Somatotrophin

GH analogue

Octreotide

somatostatin receptor ligand

Mecasermin

recombinant IGF-1

Pegmisovant

GH antagonist

Bromocriptine

dopamine agonist

Desmopressin

ADH analog

Tolvaptan

ADH receptor antagonist (V2)

Conivaptan

ADH receptor antagonist (V1a/V2)

Atosiban

oxytocin receptor antagonist used as a tocolytic agent

Terbutaline

betamimetic used as a tocolytic agent

Nifedipine

calcium channel blocker used as a tocolytic agent

Semorelin

GHRH analogue

Tesamorelin

GHRH analogue

Lanreotide

somatostatin receptor ligand

Pasireotide

somatostatin receptor ligand

Cabergoline

dopamine agonist

Semorelin and Tesamorelin are used to treat

GH deficiency

Somatotrophin is used to treat

GH deficiency

Mecasermin is used to treat

GH insensitivity that cannot be treated with GHRH or GH analogues

Octreotide, Lanreotide, and Pasireotide are used to treat

GH excess

Pegvisomant is used to treat

GH excess

Cabergoline and Bromocriptine are used to treat

prolactinomas

Desmopressin is used to treat

neurogenic diabetes insipidus

Conivaptan and Tolvaptan are used to treat

SIADH

Hydrocortisone (cortisol)

glucocorticoid receptor agonist

Dexamethasone

glucocorticoid receptor agonist

Prednisone

glucocorticoid receptor agonist

Prednisolone

glucocorticoid receptor agonist

Mifepristone

glucocorticoid receptor antagonist

Aldosterone

mineralocorticoid receptor agonist

Fludricortisone

mineralocorticoid receptor agonist

Spironolactone

mineralocorticoid receptor antagonist

Etomidate

• steroidogenesis inhibitor

• inhibits CYP11B1 conversion of progesterone to corticosterone

• decreased aldosterone

Ketoconazole

• steroidogenesis inhibitor

• many non-specific CYP inhibition

• low concentrations - decreased androgen synthesis

• high concentrations - decreased synthesis of androgen, cortisol, aldosterone

Metyrapone

• steroidogenesis inhibitor

• inhibits CYP11B1 conversion of progesterone to corticosterone

• decreased aldosterone

Mitotane

• steroidogenesis inhibitor

• inhibits synthesis of aldosterone, cortisol, androgens

Spironolactone is used to treat

Conn syndrome (excess aldosterone)

Aldosterone and Fludricortisone are used to treat

adrenal insufficiency (Addison’s disease)

Mifepristone is used to treat

glucocorticoid excess (Cushing’s syndrome)

Levothyroxine

T4

Liothyronine

T3

Methimazole

thyroid peroxidase enzyme inhibitor

Propylthiouracil

• thyroid peroxidase enzyme inhibitor

• inhibits conversion of T4 to T3

potassium iodide is used to treat

inhibits thyroid hormone synthesis via Wolff-Chaikoff effect

Propranolol is used to treat

symptoms of thyroid hormone excess

Teprotoumumab

IGF-1 receptor inhibitor, treats TED

Methimazole and Propylthiouracil are used to treat

thyroid hormone excess

Glipizide

sulfonylurea

Glyburide

sulfonylurea

Repaglinide

meglitidide

Acarbose

a-glucosidase inhibitor

Pramlintide

amylin analogue

Dulaglutide

GLP-1 receptor agonist/incretin mimetic

Semaglutide

GLP-1 receptor agonist/incretin mimetic

Tirzepatide

GLP-1 receptor agonist/incretin mimetic

Metformin

biguanide

Pioglitazone

thiazolidinedione

Sitagliptin

DPP-4 inhibitor

Canagliflozin

SGLT2 inhibitor

ethinyl estradiol

estrogen agonist

mestranol

estrogen agonist

levonorgestrel

progesterone and androgen agonist

norethindrone

progesterone and androgen agonist

norgestimate

progesterone agonist

dehydroepiandrosterone (DHEA)

androgen agonist

Oxandrolone

androgen agonist

dihydrotestosterone (DHT)

androgen agonist

tamoxifen

SERM

raloxifene

SERM

fulvestrant

SERD

clomiphene

SERM

spironolactone

androgen synthesis inhibitor

finasteride

androgen synthesis inhibitor

mifepristone

progesterone antagonist/modulator

anastrazole

aromatase inhibitor

letrazole

aromatase inhibitor

exemestane

aromatase inhibitor

flutamide

androgen antagonist

leuprolide

GnRH agonist

degarelix

GnRH antagonist

alendronate

bisphosphonate

risendronate

bisphosphonate

zolendronate

bisphosphonate

cinacalcet

calcimimetic/PAM

teriperatide

PTH analogue

abaloparatide

PTH analogue

Sevelamer

oral phosphate binder