Week_2_-_SPLecture_2_1

Biocompatibility

The ability of a material to perform with an appropriate host response when introduced into a biological environment.

Protein Affinity

Describes the likelihood with which a specific protein will adsorb to a material/tissue surface in preference to other species under specific environmental conditions.

Protein Activity

The ability of a protein to perform a specific biological function through the adoption or preservation of a specific conformation upon adsorption.

Hydrophilic Surfaces

Surfaces that tend to attract water molecules and enhance osteogenic cell adhesion.

Hydrophobic Surfaces

Surfaces that repel water, often requiring treatment to enhance cell attachment.

Conformational Change

A change in the shape of a protein that can affect its function and ability to interact with other molecules.

Protein Interlayer

The layer of proteins that forms on the surface of a material when it is introduced to a biological environment, influencing biocompatibility.

Surface Activation

The process by which an adsorbed protein enhances its binding ability and functionality through structural changes.

Isoelectric Point (pI)

The pH at which a protein carries no net electrical charge, affecting its solubility.

Molecular Weight

The weight of a molecule measured in Daltons (Da), important for determining protein characteristics and activity.

Proximity to pI

Refers to how near a protein's environment is to its isoelectric point, affecting its solubility.

Charge and Stability

Key characteristics of proteins that influence their affinity and activity in a biological context.

Competitive Species

Other proteins or molecules in solution that can compete for binding sites on a surface, affecting protein adsorption and activity.

Solvent Composition

The components of a solution that can impact protein adsorption behavior and affinity.

Electrostatics/Surface Charge

Interactions influenced by the charge properties of the protein and the material surface, significant in governing protein adsorption.