Chem 153B Unit 4

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6 Terms

1
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Methyl-directed mismatch repair

Mediated by Mut proteins; responds to methylation mismatches done by dam methylase during DNA methylation

2
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DNA methylation

Done at GATC (every 256 ish bps) by dam methylase; allows you to track mismatches

3
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MutS

Recognizes the kinks in the DNA from non-WC base pairs; uses the shape of the DNA to ID mistakes

4
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MutL

Bridges MutS and MutH to only cleave the DNA at the mistake; activates the catalytic activity of MutH

5
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MutH

reads the hemi-methylated site and cleaves the DNA at the GATC site w/ the error

6
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MutU (UvrD)

DNA helicase that keeps DNA unwound while methylation repair occurs