Kell Blood Group System

What are the 6 antigens seen in the Kell system?

K and little k

Kpa and Kpb

Jsa and Jsb

What is LITTLE k known as?

Cellano

In the Kell blood group system, which are 3 HIGH PREVALENCE antigens?

k (cellano), Kpb, and Jsb

What is seen in the K0 / Kell-null phenotype?

ABSENCE OF ALL Kell antigens

DONT have:

K and k

Kpa and Kpb

Jsa and Jsb

In cases of the K0 / Kell-null phenotype, which antigen prevalence increases?

Kx antigens

The Kx antigen attatches onto what protein on RBC membranes?

Kell glycoprotein

What is seen in the McLeod Phenotype?

ABSENT Kx with DECREASED/WEAK Kell antigens

What symptoms are seen in McLeod Phenotype (3)?

RBC abnormalities

Hemolytic anemia

Muscular/neurological abnormalities

What kind of antibody is the Anti-K?

IgG

What complications does IgG cause?

HDFN and HTR

What kind of antibodies are all other antibodies of the Kell system?

IgG

so all Kell anitbodies cause HDFN and HTR

How do the antibodies of Kell react with enzymes?

RESISTANT

At what temperature do IgGs react?

37C