steps of activation of PKA starting after the adenylyl cyclase reaction (BMED 5207 exam 4)

step 1 of activation of PKA starting after the adenylyl cyclase reaction

cAMP concentration increases

step 2 of activation of PKA starting after the adenylyl cyclase reaction

two cAMP molecules bind to each PKA regulatory subunit

step 3 of activation of PKA starting after the adenylyl cyclase reaction

the regulatory subunits move out of the active sites of the catalytic subunits and dissociate from the catalytic subunits

step 4 of activation of PKA starting after the adenylyl cyclase reaction

one of the free catalytic subunits interact with proteins to phosphorylate Ser or Thr residues and the othe rfree catalytic subunits move into the nucleus to phosphorylate CREB, activating the trasncriptoin of target genes