Pharmacology Made Easy: Phosphodiesterase Inhibitors

Flashcards summarizing key concepts and information regarding phosphodiesterase inhibitors and their use in pharmacology.

Phosphodiesterase Inhibitors

Medications like milrinone used for short-term treatment of low cardiac output in heart failure.

Therapeutic Use

To provide short-term treatment of low cardiac output in heart failure.

Adverse Drug Reactions

Hypokalemia, cardiac dysrhythmias, hypotension, and anginal chest pain.

Interventions for Milrinone

Correct fluid deficits and hypokalemia, monitor potassium levels, vital signs, ECG rhythm, and chest pain.

Administration Guidelines

Available for IV infusion only; give a loading dose over 10 minutes followed by a dose based on weight.

Client Instructions

Ongoing laboratory monitoring during infusion; report chest pain to staff.

Contraindications

Allergy to phosphodiesterase inhibitors, aortic or pulmonary valve disorder, acute MI.

Precautions

Caution in renal impairment, atrial flutter or fibrillation, and in older adults.

Interactions

Disopyramide may cause severe hypotension; incompatible with furosemide and procainamide.