Nature of Aging/Model Systems I

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Last updated 5:00 PM on 9/15/26
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4 Terms

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What are the main points of Average vs Maximum lifespan?

  • Increasing average lifespan without increasing maximum lifespan (MLS) does not usually reflect slower aging.

  • Maximum lifespan (MLS) is mainly determined by the rate of aging.

  • Maximum lifespans (MLS) are defined by the average survival of 10% of the longest-lived individuals


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What is MLS?

MLS is maximum lifespan and is defined by the average survival of 10% of the longest-lived individuals.

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Disposable Soma concept (1979)

  • Proposed by Thomas Kirkwood

  • Soma is mortal and disposable; the germ line is passed from one generation to the next

  • Think about the selfish gene



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