Erythrocyte Life Cycle

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17 Terms

1
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Where does hemopoiesis of erythrocytes begin?
In the hemopoietic bone marrow
2
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What is the order of erythrocyte precursor cells in the bone marrow, starting from the stem cell?
Stem cell, then erythroblast, then reticulocyte
3
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Which immature erythrocyte form is released from the bone marrow into the bloodstream?
Reticulocyte
4
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Where do reticulocytes mature into erythrocytes?
In the bloodstream
5
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What is the average circulation time of an erythrocyte?
120 days
6
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Which cells phagocytize old and damaged erythrocytes?
Macrophages
7
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In which three locations do macrophages phagocytize old and damaged erythrocytes?
Bone marrow, liver, and spleen
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What happens to the globin (protein) portion of hemoglobin after phagocytosis?
It is metabolized into amino acids
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What is the fate of the amino acids released from globin?
They are reused for protein synthesis
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Which portion of hemoglobin is broken down into biliverdin?
The heme portion
11
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Into what molecule is the heme portion broken down for transport in the blood?
Biliverdin
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What happens to the iron ions released from heme for transport in the blood?
They bind to the blood protein transferrin
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Which blood protein transports iron ions released from heme?
Transferrin
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In which organ is biliverdin converted to bilirubin?
The liver
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What is bilirubin used for in the liver?
To make bile
16
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Which protein stores iron ions in the liver?
Ferritin
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Besides conversion to bilirubin, what else can happen to unused heme groups?
They can be recycled and used in hemopoiesis