content 16 cancer

Cancer cells have the ability to divide uncontrollably. true or fase

true

______stay within a confined region.

tumor

_____spreads to other parts of the body.

cancer

All cancer cells behave the same way. true or false

flase

The three primary cancer therapies are: surgery, radiation, and chemotherapy. true or false

true

Necrosis definition

Accidental, uncontrolled cell death

Apoptosis definition

programmed, regulated cell death

cause of Necrosis

due to severe damage (toxin, trauma, infection)

cause for Apoptosis

normal developmental process or response to cellular stress

cell morphology necrosis

cells swell and rupture

cell morphology apoptosis

cells shrink and form blebs

intracellular content release necrosis

spills into surrounding tissue

intracellular content release apoptosis

contained within apoptotic bodies

inflammatory response necrosis

yes, triggers inflammation

inflammatory response apoptosis

no, avoids inflammation

biological roles necrosis

occurs due to injury, harmful to the organism

biological roles apoptosis

essential for development, tissue maintenance, and removing damaged cells

1)        p53 is a protein that senses DNA damage and inhibits cells from dividing if the DNA is not repaired.  Is p53 an oncogene or tumor suppressor?

tumor suppressor

Ras is a protein that signals cells to undergo cell division.  Ras is activated when it is bound to an energy currency GTP.  Ras gene can become mutated so that Ras is continuously bound to GTP.  Is Ras an oncogene or tumor suppressor?

oncogene

Pretend you are a scientist and you have identified a mutation in the gene “UNKNOWN101” within a sample of cancer cells and aim to determine its role in cancer progression. To investigate whether UNKNOWN101 functions as a tumor suppressor gene or an oncogene, you generate knockout (KO) cells by depleting (deleting) the gene and subsequently measure cell proliferation (how fast cells grow).  You compare this to normal wildtype (WT) cells.  Based on the data provided above, does UNKNOWN101 exhibit characteristics of a tumor suppressor gene or an oncogene?  

tumor suppressor gene