quiz 2 pharm lab

what is linctus aka Diphenhydramine Hydrochloride Linctus

• a clear syrup with strawberry flavor

• relieves symptoms of allergies such as runny nose and sneezing

• is used for symptom relief of common cold and cough.

what is Linctus considered

• viscous

• thick

approximate shelf life for Linctus

• 2 weeks

• beyond 2 weeks it does guarantee safety

side effect of Linctus

may cause drowsiness

LABELING OF DRUG PRODUCTS

• includes how to use the medication

• give info regarding the medication

• contains information for the patient's safe and effective use of the medicine

why is labeling important to the patient

• patients’ best source (and often only source) of information regarding the medications

what specfic contents do the label also point out

• alcohol and ethanol content

• state sugar for diabetes

expiration date

• the date after which a product shall not be used when stored under the prescribed storage conditions.

• determined after stability analysis under several conditions

beyond use date

• This date is used on compounded products when extensive stability studies are not performed to determine storage duration.

• involves lab work

beyond use date

shall not be later than the expiration date on the manufacturer's container.

what should you avoid using?

decimals

ex: write 4 instead of 4

ex: instead of 0.45 mg write 450 mcg

salic acid

• soluble in H2O

• could cause drozziness

• bitter

where does salic acid need to be stored?

amber bottle/ light senstive

citric acid use

adjust pH for diphenydrine

sodium benzoate is considered a

preservative

• one of the most common ones

Related for the target population

(not on quiz)

• dose

• administration

• volume

• patient appeal

Related for the target API

(not on quiz)

• solubility

• stability and compatibility

•  storage

• warnings

• toxicity ( limits that apply)

• patient appeal and requirements

• other issues

Related for the techniques and available resources

(not on quiz)

• room conditions

• device precision and accuracy

• manipulations ( heating, mixing etc)

sweetners example:

• Sucrose

• Fructose

• Glucose/Dextrose

• Glycerin/Glycerol

• Sorbitol

• Saccharin

• Cyclamates

• Aspartame

• Acesulfame

• Sucralose

example of preservatives

• Benzalkonium chloride

• Butyl paraben

• Benzyl alcohol

• Methyl paraben

• Cetylpyridinium

• chloride

• Ethyl paraben

• Chlorobutanol

• Propyl paraben

• Ethyl alcohol

• Benzoic acid

• Glycerin

• Potassium sorbate

• Phenol

• Sodium benzoate (emphasized in class)

• Propylene glycol

• Sodium propionate

• Thimerosal

• Sorbic acid

0.1–0.25%

Methyl paraben, Ethyl paraben, Propyl paraben

0.1–0.2% w/w

Potassium sorbate, Sodium benzoate

0.1–0.5% w/w

Phenol, Benzoic acid

0.1–0.4% w/w

Butyl paraben

0.05–0.2% w/w

Sorbic acid

0.10% w/w

Thimerosal

0.002–0.02% w/w

Benzalkonium chloride

0.0005–0.0007% w/w

Cetylpyridinium chloride

0.50% w/w

Chlorobutanol

3.00% w/w

Benzyl alcohol

15–20% w/w

Ethyl alcohol

20–30% w/w

Glycerin

15–30% w/w

Propylene glycol

5–10% w/w

Sodium propionate