Ceutics Exam 2 Sample Questions

Which capsule size has the smallest capacity? C1

(A) 5

(B) 4

(C) 1

(D) 0

(E) 000

A. 5

Rectal suppositories intended for adult use usually weigh… S1

A. 1g

B. 2g

C. 3g

D. 4g

E. 5g

B. 2g

What may happen when hard gelatin capsules are stored under very low humidity? C1

(A) The shells become excessively soft.

(B) The shells lose moisture and become brittle.

(C) The shells become enteric-coated.

(D) The drug’s solubility always increases.

(B) The shells lose moisture and become brittle.

Which statement correctly describes hard gelatin capsules? C1

(A) They consist of a single sealed shell.

(B) They typically have two parts: a body and a cap.

(C) They can contain only liquid medications.

(D) They do not require disintegration before releasing their

contents

(B) They typically have two parts: a body and a cap.

How can viscosity affect a rectal dosage form? S2

I. If too high, drug release may be slow

II. Is needed to help ensure uniformity of suspensions during preparation

III. Helps minimize degradation of the drug

I. If too high, drug release may be slow

II. Is needed to help ensure uniformity of suspensions during preparation

In the fusion method of making cocoa butter suppositories, which substance is most likely to be used to lubricate the mold? S2

(A) mineral oil

(B) propylene glycol

(C) cetyl alcohol

(D) stearic acid

(E) magnesium silicate

(B) propylene glycol

A satisfactory suppository base must meet all of the following criteria except… S2

(A) it should have a narrow melting range.

(B) it should be nonirritating and nonsensitizing.

(C) it should dissolve or disintegrate rapidly in the body cavity.

(D) it should melt< 30°C.

(E) it should be inert.

(D) it should melt< 30°C.

Cocoa butter (theobroma oil) exhibits all of the following properties except… S2

(A) it melts at temperatures between 33°C and 35°C.

(B) it is a mixture of glycerides.

(C) it is a polymorph.

(D) it is useful in formulating rectal suppositories.

(E) it is soluble in water.

(E) it is soluble in water.

When administered rectally, at least what percent of the active ingredients will be absorbed? S1

(A) Less than 10%

(B) 10-25%

(C) 25-50%

(D) 50-70%

(E) More than 70%

(D) 50-70%

The rectal route of administration of drug may be preferred over the oral route for some systemic-action because… S1

(A) the drug does not have to be absorbed

(B) absorption is predictable and complete

(C) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

(D) the dissolution process is avoided.

(C) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

Advantages of systemic drug administration by rectal suppositories include S2

I. avoidance of first-pass effects.

II. suitability when the oral route is not feasible.

III. predictable drug release and absorption.

I. avoidance of first-pass effects.

II. suitability when the oral route is not feasible.

Which type of paper best protects a divided hygroscopic powder? PG1

(A) waxed paper

(B) glassine

(C) white bond

(D) blue bond

(E) vegetable parchment

(A) waxed paper

Substances used to insulate powder components that liquefy when mixed include… PG1

I. talc.

II. kaolin.

III. light magnesium oxide.

II. kaolin.

III. light magnesium oxide.

A ceramic mortar may be preferable to a glass mortar when… PG1

I. a volatile oil is added to a powder mixture.

II. colored substances (dyes) are mixed into a powder.

III. comminution is desired in addition to mixing.

III. comminution is desired in addition to mixing.

Divided powders may be dispensed in… PG1

I. individual-dose packets.

II. a bulk container.

III. a perforated, sifter-type container.

I. individual-dose packets.

A sweetener that is widely employed in chewable tablet formulas is… T1

A) aspartame

B) glucose

C) lactose

D) mannitol

E) sucrose

D) mannitol

True statements about the function of excipients used in tablet formulations include… T1

I. binders promote granulation during the wet granulation process

II. glidants help promote the flow of the tablet granulation during manufacture

III. lubricants help the patient swallow the tablets

I. binders promote granulation during the wet granulation process

II. glidants help promote the flow of the tablet granulation during manufacture

Which manufacturing variables would be likely to affect the dissolution of a prednisone tablet in the body? T1

I. the amount and type of binder added

II. the amount and type of disintegrant added

III. the force of compression used during tableting

All statements are true

The shells of soft gelatin capsules may be made elastic or plastic-like by the addition of... C2

(A) sorbitol.

(B) povidone.

(C) polyethylene glycol (PEG).

(D) lactose.

(E) hydroxypropyl methylcellulose.

(A) sorbitol.

Why is good powder flow important when filling hard capsules? C2

(A) It improves the color of the capsule shell.

(B) It prevents all drug degradation.

(C) It helps achieve consistent fill weights.

(D) It eliminates the need for quality testing

(C) It helps achieve consistent fill weights.

What is the primary purpose of a capsule dissolution test? C2

(A) To measure the force required to break the capsule

(B) To determine the uniformity of capsule color

(C) To measure how much drug dissolves in a specified medium over time

(D) To measure the moisture content of the capsule shell

(C) To measure how much drug dissolves in a specified medium over time

Dose dumping is a problem in the formulation of… T3

(A) compressed tablets

(B) modified-release drug products

(C) hard gelatin capsules

(D) soft gelatin capsules

(E) suppositories

(B) modified-release drug products

The United States Pharmacopeia (USP) content uniformity test for tablets is used to ensure which quality? T2

(A) bioequivalency

(B) dissolution

(C) potency

(D) purity

(E) toxicity

(D) purity

Which tablet quality tests are described in USP informational chapters and primarily assess resistance to mechanical damage? T2

(A) Disintegration and dissolution

(B) Dissolution and assay

(C) Tablet breaking force (hardness) and friability

(D) Identification and content uniformity

(E) Content uniformity and weight variation

(C) Tablet breaking force (hardness) and friability

Which condition usually increases the rate of drug dissolution from a tablet? T2

(A) increase in the particle size of the drug

(B) decrease in the surface area of the drug

(C) use of the free acid or free base form of the drug

(D) use of the ionized, or salt, form of the drug

(E) use of sugar coating around the tablet

(D) use of the ionized, or salt, form of the drug

The rate-limiting step in the bioavailability of a lipid soluble drug formulated as an immediate-release compressed tablet is the rate of… T2

(A) disintegration of the tablet and release of the drug.

(B) dissolution of the drug.

(C) transport of the drug molecules across the intestinal mucosal cells.

(D) blood flow to the gastrointestinal tract.

(E) biotransformation, or metabolism, of the drug by the liver

before systemic absorption occurs.

(B) dissolution of the drug.