GI drugs

Histamine 2 receptor antagonist drugs

end in tidine, famotidine, cimetidine, nizatidine, ranitidine

Histamine 2 receptor antagonist properties

suppresses secretion of gastric acid and blocks histamine

Histamine 2 receptor antagonist effects

binds with other meds

Histamine 2 receptor antagonist contradictions

med incompatabilities

Histamine 2 receptor antagonist nursing info

give 1 hr before or after other meds

what are Histamine 2 receptor antagonists used for

GERD, ZE syndrome and PVD

Proton Pump Inhibitor drugs

end in prazole, omeprazole, esomeprazole, lansoprazole, pantoprazole

Proton Pump Inhibitor properties

allow for healing, most effective for suppressing secretion of gastric acid, irreversible inhibition of H, K and ATPase, blocks final pathway of acid production

Proton Pump Inhibitor effects

consipation is most common, HA, diarrhea, N/V, dec B12 leading to pernicious anemia

Proton Pump Inhibitor contradictions

avoid alcohol, smoking, eating fast and eating before bed

Proton Pump Inhibitor nursing info

give 1 hr before or after other meds, meant for prevention

what is Proton Pump Inhibitors used for

prevention of ulcers, GERD, ZE syndrome

mucosal protectant drugs

sucralfate

mucosal protectant properties

creates protective barrier against acid and pepsin, bandaid for stomach, has no acid neutralizing properties or ability to dec acid secretion

mucosal protectant effects

constipation

mucosal protectant contradictions

dec absorption of fat soluble vitamins and other drugs

mucosal protectant nursing info

give on empty stomach, create slurry

anti secretory agent drugs

misoprotsol

anti secretory agent properties

inc mucus, synthetic prostaglandin, prevents NSAID ulcers

anti secretory agent effects

diarrhea, abd pain and spotting

anti secretory agent contradictions

not safe in pregnancy

anti secretory agent nursing info

give with meals

serotonin receptor antagonist drugs

end in tron, ondansetron, granistron, dolasetron

serotonin receptor antagonist properties

anti emetics, anti nausea, blocks 5HT3 receptors, for N/V because of chemo

serotonin receptor antagonist effects

QT prolong so give Mg, serotonin syndrome so don’t combine with SSRIs

serotonin receptor antagonists nursing info

reduce transmission of n/v signal, doxamethason used to inc effectiveness

dopamine antagonist drugs

metoclopramide, prochlarperazine, promethazine

dopamine antagonist properties

move food, inc mastic mobility, pro kinetic agent, anti emetic

dopamine antagonist effects

EPS treat with Benadryl, twitching

dopamine antagonist nursing info

watch BP and HR

somatostatin analog drugs

octreotide

somatostatin analog properties

reduce portal venous pressure and splanchnic blood flow to help control variceal bleeding, vasoconstriction of GI blood vessels and dec bleeding

somatostatin analog effects

abd pain, n/v/d, brady, gallstones, hypothyroidism

somatostatin analog nursing info

watch gallbladder, DM, thyroid and cardiac

ADH vasoconstrictor drugs

vasopressin

ADH vasoconstrictor properties

vasoconstriction of splanchnic vessels, dec bleeding for gastric varies, systemic

ADH vasoconstrictor effects

HTN, Brady, coronary vascospasm, myocardial ischemia, N/V, dec urine