PI3K signaling pathway through AKT (BMED 5207 exam 4)

step 1 of PI3K signaling pathway through AKT

PI3K is activated by binding of its SH2 domain to phosphotyrosines on activated RTKs and cytokine receptors

step 2 of PI3K signaling pathway through AKT

activated PI3K catalyzes phosphorylation of PI(4,5)P2 to generate the second messenger PIP3

step 3 of PI3K signaling pathway through AKT

PIP serves as a docking site for PH domain containing AKT and PDK1, bringing them into proximity at the plasma membrane

step 4 of PI3K signaling pathway through AKT

AKT is partially activated by PDK1 mediated phosphorylation at Thr308

step 5 of PI3K signaling pathway through AKT

AKT is fully activated by phosphorylation at Ser483 by its downstream effector mTORC2

step 6 of PI3K signaling pathway through AKT

AKT phosphorylates many cytoplasmic and nuclear proteins to regulate their activities