Skills III Drug List 2: anticoagulation, antiplatelet, bleeding, diuretics

Activase

alteplase

Cathflo Activase

alteplase

Amicar

aminocaproic acid

Eliquis

apixaban

Acova

argatroban

Angiomax

bivalirudin

Bumex

bumetanide

Plavix

clopidogrel

DDVAP

desmopressin

Nocdurna

desmopressin

Lovenox

enoxaparin

Integrilin

eptifibatide

Arixtra

fondaparinux

Lasix

furosemide

Zaroxolyn

metolazone

Xarelto

rivaroxaban

TNKase

tenecteplase

Demadex

torsemide

Cyklokapron

tranexamic acid

Lysteda

tranexamic acid

Coumadin

warfarin

Jantoven

warfarin

indication for alteplase

• acute ischemic stroke

• ST-elevation MI

• pulmonary embolism

• central venous catheter clearance

indication for aminocaproic acid

acute bleeding

indication for apixaban

• nonvalvular atrial fibrillation

• DVT

• pulmonary embolism

• postoperative venous thromboprophylaxis post hip or knee replacement

indication for argatroban

• heparin-induced thrombocytopenia (HIT)

• percutaneous coronary intervention (PCI)

indication for bumetanide

• edema

• volume overload

indication for clopidogrel

• acute coronary syndrome

• STEMI, NSTEMI, MI

• ischemic stroke/transient ischemic attack

• peripheral atherosclerotic disease

indication for desmopressin

• hemophilia A

• Von Willebrand Disease

• diabetes insipidus

• nocturia

indication for enoxaparin

• acute coronary syndrome

• DVT

• pulmonary embolism

• venous thromboembolism (VTE) prophylaxis

indication for eptifibatide

• acute coronary syndrome

• percutaneous coronary intervention (PCI)

indication for fondaparinux

• acute coronary syndrome

• DVT

• pulmonary embolism

• heparin-induced thrombocytopenia (HIT)

• venous thromboembolism (VTE) prophylaxis

indication for furosemide

• edema

• HF

• HTN

indication for heparin

• venous thromboembolism (VTE) prophylaxis

• DVT

• pulmonary embolism

• prophylaxis/treatment of other thromboembolic disorders

indication for metolazone

• edema

• general volume overload

• HF

• renal diseases

indication for rivaroxaban

• Afib

• stable coronary artery disease

• stable peripheral artery disease

• indefinite anticoagulation

• DVT

• pulmonary embolism

• venous thromboembolism (VTE) prophylaxis in hip or knee arthroplasty

indication for tenecteplase

• STEMI

• acute ischemic stroke

• pulmonary embolism - associated with cardiac arrest

indication for torsemide

• edema

• volume overload

• HTN

indication for tranexamic acid

• abnormal uterine bleeding

• postpartum hemorrhage

• hemostasis

• trauma-associated hemorrhage

indication for warfarin

• prophylaxis and treatment of thromboembolic disorders

• reduce risk of embolism in recurrent MI or stroke

dosing for alteplase

• IV acute ischemic stroke: 0.9 mg/kg x1 dose

• Catheter occlusion: 1-2 mg over 30-60 mins

dosing for aminocaproic acid

PO/IV: 4-5 g loading dose followed by 1 g/hr (max dose 30 g/day)

dosing for apixaban

• PO Afib: 2.5 - 5 mg BID

• PO treatment: 10 mg BID x 7 days, then 5 mg BID

dosing for argatroban

IV continuous infusion: 0.25 - 2 mcg/kg/min

dosing for bivalirudin

IV: 0.75 mg/kg bolus followed by 0.25 - 1.75 mg/kg/hr

dosing for bumetanide

• PO: 0.5 - 2 mg Q8-24H (Max 10 mg/day)

• IV push: 0.5 - 1 mg x 1 dose (Max 10 mg)

• IV continuous infusion: 0.5 - 1 mg/hr

dosing for clopidogrel

• PO loading dose: 300 - 600 mg x 1 dose

• PO: 75 mg QD

dosing for desmopressin

• PO: 0.05 - 0.2 mg QD HS

• IV/SQ: 0.3 mcg/kg x 1 dose 30-60 mins before procedure - hemophilia/Von Willebrand disease

• IV/SQ: 0.25 - 1 mcg Q12-24H - diabetes insipidus

• Intranasal: 10 - 20 mcg Q12-24H - diabetes insipidus

dosing for enoxaparin

• SQ prophylaxis: 30 - 40 mg QD

• SQ treatment: 1 mg/kg Q12H or 1.5 mg/kg QD

dosing for eptifibatide

IV: 180 mcg/kg bolus then 1-2 mcg/kg/min

dosing for fondaparinux

SQ: 2.5 - 10 mg QD

dosing for furosemide

• PO: initial 20 - 40 mg QD

• IV push: 1 - 2.5x oral maintenance dose

• IV continuous infusion: 2 - 20 mg/hr

dosing for heparin

• SQ prophylaxis: 5,000 units Q8-12H

• IV continuous infusion: 60 - 80 units/kg bolus, then 12 - 18 units/kg/hr

dosing for metolazone

PO: initial 2.5 - 5 mg QD, may increase to max of 20 mg/kg/day in 1-2 divided doses

dosing for rivaroxaban

• PO Afib: 20 mg QD

• PO treatment: 15 mg BID x 21 days, then 20 mg QD

dosing for tenecteplase

IV bolus: 30 - 50 mg x1 dose

dosing for torsemide

PO: initial 5-20 mg QD, may increase to max 100 mg BID

dosing for tranexamic acid

• PO: 1.3 g TID for up to 5 days

• IV: loading dose 1000 mg over 10 mins, then 1000 mg continuous infusion for 8 hours

dosing for warfarin

PO: 1 - 10 mg QD, target INR per indication