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What causes changes in membrane potential?
Opening of Na+ or K+ gated channels allowing ions to flow across the plasma membrane
What does ion flow across the membrane generate?
Changes in membrane potential and an electrical signal that conducts sensory or motor information
What is the resting membrane potential of a neuron?
-70 mV
What terms describe changes in membrane potential?
Depolarisation
Hyperpolarisation
What is depolarisation?
Membrane potential becomes less negative

What causes depolarisation?
Opening of Na+ gated channels
Influx of Na+ ions into the ICF
What happens to the ICF during depolarisation?
ICF gains positive ions; Cell interior becomes less negative
What happens to membrane potential during depolarisation?
Becomes less negative (e.g., -70 mV to -60 mV)
What is hyperpolarisation?
Membrane potential becomes more negative

What causes hyperpolarisation?
Opening of K+ gated channels
Efflux of K+ ions out of the ICF
What happens to the ICF during hyperpolarisation?
ICF loses positive ions
Cell interior becomes more negative
What happens to membrane potential during hyperpolarisation?
Becomes more negative (e.g., -70 mV to -80 mV)
Why do ions flow across the plasma membrane?
Ions flow down their concentration gradient