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Neuron
a nerve cell; the basic building block of the nervous system
Cell Body
the part of a neuron that contains the nucleus; the cell’s life-support center
dendrites
a neuron’s often bushy, branching extensions that receive and integrate messages, conducting impulses toward the cell body.
axon
the segmented neuron extension that passes messages through its branches to other neurons or to muscles or glands
myelin sheath
a fatty tissue layer segmentally encasing the axons of some neurons; it enables vastly greater transmission speed as neural impulses hop from one node to the next.
glial cells (glia)
cells in the nervous system that support, nourish, and protect neurons; they may also play a role in learning, thinking, and memory
action potential
a neural impulse; a brief electrical charge that travels down an axon
threshold
the level of stimulation required to trigger a neural impulse
refractory period
in neural processing, a brief resting pause that occurs after a neuron has fired; subsequent action potentials cannot occur until the axon returns to its resting state
all-or-none response
a neuron’s reaction of either firing (with a full-length strength response) or not firing.
synapse
the junction between the axon tip of the sending neuron and the dendrite or cell body of the receiving neuron. the tiny gap at this junction is called the synaptic gap or synaptic cleft.
neurotransmitters
chemical messengers that cross the synaptic gap between neurons. when released by the sending neuron, they travel across the synapse and bind receptor sites on the receiving neuron, thereby influencing whether that neuron will generate a neural impulse.
reuptake
a neurotransmitter’s reabsorption by the sending neuron
endorphins
natural, opioid-like neurotransmitters linked to pain control and to pleasure; “morphine within”
agonist
a molecule that increases a neurotransmitter’s action
antagonist
a molecule that inhibits or blocks a neurotransmitter’s action
endocrine system
the body’s “slow” chemical communication system; a set of glands and fat tissue that secrete hormones into the bloodstream
hormones
chemical messengers that are manufactured by the endocrine glands, travel through the bloodstream, and affect other tissues.
psychoactive drug
a chemical substance that alters the brain, causing changes in perceptions and moods
substance use disorder
a disorder characterized by continued substance use despite resulting life disruption
depressants
drugs that reduce neural activity and slow body functions
tolerance
the diminishing effect with regular use of the same dose of a drug, requiring the user to take larger and larger doses before experiencing the drug’s effect
addiction
an everyday term for compulsive substance use (and sometimes for dysfunctional behavior patterns, such as out-of-control gambling) that continue despite harmful consequences
withdrawal
the discomfort and distress that follow discontinuing an addictive drug or behavior.
barbiturates
drugs that depress central nervous system activity, reducing anxiety but impairing memory and judgement
opioids
opium and its derivatives; they depress neural activity, temporarily lessening pain and anxiety
stimulants
drugs that excite neural activity and speed up body functions
hallucinogens
psychedelic (“mind manifesting”) drugs that distort perceptions and evoke sensory images in the absence of sensory input
near-death experience
an altered state of consciousness reported after a close brush with death (such as a cardiac arrest); often similar to drug-induced hallucinations
Acetylcholine (ACh)
Muscle movement, learning, memory, and attention.
Dopamine
Movement, reward, motivation, attention, and learning.
Serotonin
Regulates mood, sleep, appetite, and arousal
GABA
Main inhibitory neurotransmitter; slows and calms neural activity.
Glutamate
Main excitatory neurotransmitter; increases neural activity and helps with learning and memory.
Substance P
Transmits pain signals from the body to the brain.
Agonist (function)
Increases or mimics a neurotransmitter's effects
Norepinephrine
Alertness, arousal, attention, and the stress response.