IMB review section 8

What viruses have live attenuated vaccine?

MMR, varicella, OPV, rotavirus, yellow fever, vaccinia

What protection do the live attenuated vaccines lead to?

IgG, IgA, plus CTLs and memory

What are the risks of live attenuated vaccine? Who are not given live attenuated vaccine?

reversion and avoided in immunocompromised and pregnant people

What viruses have killed/inactivated vaccines?

IPV, hepatitis A, rabies, flu shot, japanese encephalitis

What protection do the live attenuated vaccines lead to?

IgG, little IgA or CTL, and boosters needed

What are the antigens for subunit/recombinant/VLP vaccines?

HBsAg, HPV L1, Novavax

What protection is given by subunit/recombinant/VLP vaccines?

safe and gives IgG

What are the properties of polysaccharide vaccines?

T-independent, gives IgM and IgG2, no memory and poor response in infants

What are the properties of a conjugate vaccine?

T cell help, class switching to IgG1 and IgG3, memory B cells, and works in infants

What are the properties of the mRNA and adenovirus-vector vaccines?

cells make spike internally, giving MHCI cd8 and MHC 2 cd4 presentation plus antibody. adenovirus vectors deliver dna